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Bioinformatics: From Nucleic Acids and Proteins to Cell Metabolism
Bioinformatics, in this context the application of computer science to biological problems, has become an indispensable part of any research in the biosciences. Rapid developments in gene sequencing, structure determination as well as rational protein engineering and design have made it necessary for biologists, chemists, and computer scientists to channel their expertise into large scale collaborative projects. This GBF Monograph gives a general overview of the latest versatile activities in bioinformatics: * Biological Data Bases * DNA and RNA * Protein Sequences and Structures * From Molecules to Cell Metabolism The articles have been selected from contributions to a conference on Bioinformatics/Computer Application in the Biosciences, held in October 1995 in Braunschweig at the German National Research Center for Biotechnology.
Virtual Screening
Drug discovery is all about finding small molecules that interact in a desired way with larger molecules, namely proteins and other macromolecules in the human body. If the three-dimensional structures of both the small and large molecule are known, their interaction can be tested by computer simulation with a reasonable degree of accuracy. Alternatively, if active ligands are already available, molecular similarity searches can be used to find new molecules. This virtual screening can even be applied to compounds that have yet to be synthesized, as opposed to "real" screening that requires cost- and labor-intensive laboratory testing with previously synthesized drug compounds. Unique in its...
The Communist Successor Parties of Central and Eastern Europe
What has become of the Communist parties that once held monopoly power in the east bloc? A decade ago, it was assumed that they would dissolve, but many of them have enjoyed electoral success. This book systematically examines how they have evolved. In the opening section, Herbert Kitschet and Ivan Szelenyi respectively consider post-communist party strategies and social democratic prospects in the transitional societies. Part II presents nine case studies of the major communist and communist successor parties of the region, and Part III is devoted to seven comparative studies. Appendices provide comparable electoral and party membership data.
De novo Molecular Design
Systematically examining current methods and strategies, this ready reference covers a wide range of molecular structures, from organic-chemical drugs to peptides, Proteins and nucleic acids, in line with emerging new drug classes derived from biomacromolecules. A leader in the field and one of the pioneers of this young discipline has assembled here the most prominent experts from across the world to provide first-hand knowledge. While most of their methods and examples come from the area of pharmaceutical discovery and development, the approaches are equally applicable for chemical probes and diagnostics, pesticides, and any other molecule designed to interact with a biological system. Num...
Virtual Screening: An Alternative or Complement to High Throughput Screening?
In the next couple of years the human genome will be fully sequenced. This will provide us with the sequence and overall function of all human genes as well as the complete genome for many micro-organisms. Subsequently it is hoped, by means of powerful bioinformatic tools, to determine the gene variants that contribute to various multifactorial diseases and genes that exist in certain infectious agents but not humans. As a consequence, this will allow us to define the most appropriate levels for drug intervention. It can be expected that the number of potential drug targets will increase, possibly by a factor of 10 or more. Nevertheless, sequencing the human genome or, for that matter, the g...
Proceedings in Print
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Die PDS
Während wir uns im Endstadium der Korrekturarbeiten zu diesem Buch befanden, forderte Altbundespräsident Richard von Weizsä cker im Interesse der deutschen Einheit zu einem kooperativen Umgang mit der PDS auf. Er tat dies kurz nach der Wahl zum Ab geordnetenhaus und zu den Bezirksverordnetenversammlungen in Berlin, bei der die PDS ihre starke Stellung im Ostteil der Stadt behaupten konnte, und brachte damit zum Ausdruck, was auch wir mit diesem Buch anstreben: eine nüchterne Betrachtungsweise der Partei, die nicht nur das Erbe ihrer Vorgängerin SED verwaltet, sondern zugleich am Parteienwettbewerb in der Bundesrepublik teilnimmt und als politische Sachwalterin einer starken Minderheit in Ostdeutschland wichtige Repräsentations-und Integrationsauf gaben innerhalb der bundesdeutschen Demokratie wahrnimmt. Bei der Durchführung unserer Untersuchungen haben wir von vielen Seiten, nicht zuletzt aus den Reihen der PDS, hilfreiche Unterstützung erfahren. Wir danken allen, die uns geholfen haben, insbesondere aber Ursula Böhme für ihre ebenso kritische wie akribische Durchsicht des Manuskripts.
Der Bundestagswahlkampf 1998
Die Arbeit behandelt die Strategien und Kampagnen der im 14. Deutschen Bundestag vertretenen Parteien zur Bundestagswahl vom 27. September 1998. Dargestellt und untersucht werden für die beiden "großen" Parteien SPD und CDU die Frage nach den Kanzlerkandidaten, die Kampagnestrategien inklusive der Koalitionsstrategie und die Wahlkampforganisation. Die Strategien der drei "kleinen" Parteien Bündnis 90/Die Grünen, FDP und PDS werden in einem eigenständigen Kapitel behandelt. In gleicher Weise werden die landespolitischen Einflüsse auf die Bundestagswahl 1998 untersucht.
