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Drug Design - From Structure and Mode-of-Action to Rational Design Concepts
This English-language textbook, based on the successful German edition 'Wirkstoffdesign', brings the subject of drug design back to the cutting edge of research. The reader learns about new methods in genetic engineering and the expanded range of structural biological methods. Especially in the last 10 years, many complex target structures such as G-protein coupled receptors or ion channels have been elucidated by using these methods. The reader learns how these long-sought complex structures with classical drugs look like and how the therapeutic effect is achieved. This textbook is aimed at students of pharmacy, chemistry and the life sciences, but also at career changers and medicinal chem...
Wirkstoffdesign
Dieses für den deutschen Raum einzigartige Lehrbuch richtet sich an Studenten der Pharmazie, Chemie und Biowissenschaften, aber auch an Quereinsteiger in Forschungs- und Entwicklungsabteilungen der Pharmazeutischen Industrie. Die zweite Auflage ist komplett überarbeitet. Zahlreiche aktuelle Entwicklungen vor allem im methodischen Bereich sind zum Teil in neuen Kapiteln aufgegriffen, viele Fallbeispiele machen die Theorien und Verfahren anschaulich und nachvollziehbar. Der Bogen spannt sich von der Geschichte der Arzneimittelforschung, den Wirkmechanismen der Arzneistoffe und den Methoden zur Leitstruktursuche und -optimierung über Strukturbestimmungsmethoden, Modelling, Moleküldynamik un...
From Molecules to Medicines
Proceedings of the NATO Advanced Study Institute on Integrating Crystallography in the Fight Against Terrorism Erice, Italy 29 May-8 June 2008
Virtual Screening: An Alternative or Complement to High Throughput Screening?
In the next couple of years the human genome will be fully sequenced. This will provide us with the sequence and overall function of all human genes as well as the complete genome for many micro-organisms. Subsequently it is hoped, by means of powerful bioinformatic tools, to determine the gene variants that contribute to various multifactorial diseases and genes that exist in certain infectious agents but not humans. As a consequence, this will allow us to define the most appropriate levels for drug intervention. It can be expected that the number of potential drug targets will increase, possibly by a factor of 10 or more. Nevertheless, sequencing the human genome or, for that matter, the g...
Index of Patents Issued from the United States Patent Office
pt. 1. List of patentees.--pt. 2. Index to subjects of inventions.
Die Abbildungen Des Buches "Wirkstoffdesign"
Die Bild-DVD-ROM zur 2. Auflage des Lehrbuches Wirkstoffdesign von Gerhard Klebe erm glicht Dozenten, die Abbildungen des Buches in der Lehre zu nutzen sei es in Form von Folien, Dias, Ausdrucken oder ber einen Beamer. Die Zeichnungen k nnen damit den Unterricht st tzen und bereichern. Die im JPEG- und PDF-Format sowie als PowerPoint-Folien gespeicherten Abbildungen sind entsprechend ihrer Nummerierung im Buch sortiert und dar ber hinaus auch ber die Inhalte der Bildunterschriften recherchierbar. Sie k nnen so leicht in Pr sentationen eingebaut oder in unterschiedlicher Gr e mit oder ohne Legende ausgedruckt werden. Die Bild-DVD-ROM kann nat rlich auch f r Studenten zur Vorbereitung von Vortr gen und Referaten n tzlich sein. Die 2. Auflage des Lehrbuches Wirkstoffdesign ist erh ltlich unter der ISBN 978-3-8274-2046-6.
Supramolecular Structure and Function 9
The book is based on International Summer Schools on Biophysics held in Croatia which, contrary to other workshops centered mainly on one topic or technique, has very broad scope providing advanced training in areas related to biophysics. This volume presents papers in the field of biophysics for studying biological phenomena by using physical methods and/or concepts. Its scope should be of interest for students at doctoral or postdoctoral level and to experienced scientists.
3D QSAR in Drug Design
Significant progress has been made in the study of three-dimensional quantitative structure-activity relationships (3D QSAR) since the first publication by Richard Cramer in 1988 and the first volume in the series, 3D QSAR in Drug Design. Theory, Methods and Applications, published in 1993. The aim of that early book was to contribute to the understanding and the further application of CoMFA and related approaches and to facilitate the appropriate use of these methods. Since then, hundreds of papers have appeared using the quickly developing techniques of both 3D QSAR and computational sciences to study a broad variety of biological problems. Again the editor(s) felt that the time had come t...
Proceedings of the 6th Asia-Pacific Bioinformatics Conference
High-throughput sequencing and functional genomics technologies have given us the human genome sequence as well as those of other experimentally, medically, and agriculturally important species, thus enabling large-scale genotyping and gene expression profiling of human populations. Databases containing large numbers of sequences, polymorphisms, structures, metabolic pathways, and gene expression profiles of normal and diseased tissues are rapidly being generated for human and model organisms. Bioinformatics is therefore gaining importance in the annotation of genomic sequences; the understanding of the interplay among and between genes and proteins; the analysis of the genetic variability o...
Advances in Molecular Nanotechnology Research and Application: 2013 Edition
Advances in Molecular Nanotechnology Research and Application: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Molecular Motors. The editors have built Advances in Molecular Nanotechnology Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Molecular Motors in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Molecular Nanotechnology Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
