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Imaging in Parkinson's Disease
Imaging in Parkinson's Disease provides up-to-date information concerning new applications of brain imaging to the study of Parkinson's disease. Written by experts in the field, the book focuses on structural and functional imaging methodologies that have recently been applied to study the natural history of Parkinson's disease, with emphasis on the development of the major motor manifestations of the illness as well as cognitive impairment and dementia. Individual chapters address the role of imaging in differential diagnosis and in the evaluation of pharmacologic and surgical treatment effects. In-depth discussion of the use of imaging tools to study disease mechanisms is also provided, wi...
Clinical Applications of Functional Brain MRI
Over the past few years FMRI has become one of the most widely used methods for imaging normal brain function, in turn becoming a valuable tool in the study of many psychiatric and neurological disorders. This book provides an overview of the latest FMRI research in a number of these disorders.
Clinical Trials in the Neurosciences
A properly designed and executed clinical trial that addresses an import question and delivers a definitive result can change the practice of medicine worldwide. This book encompasses a bench-to-bedside approach and serves as an excellent guidance for translating preclinical studies to early phase I/II and phase III trials. In the first part, the book covers preclinical science with respect to animal models of various neurological diseases, FDA requirements for preclinical studies, translation of animal to patient studies and scaling up from animal to human studies. In the second part, the design of phase I/II trials and the use of biomarkers as surrogate endpoints are discussed. With regard...
Microquasars
The Third Microquasar Workshop (or the 'Fifth' Workshop on Galactic Relativ istic Jet Sources), was held in Granada, Andalucia (Spain) on 11-13 September 2000. The aim of this workshop in Granada, following the previous Microquasar Workshops in Greenbelt (1997) and Paris (1998) and the Workshops on galactic sources with relativistic jets in Jodrell Bank (1996) and Milton Keynes (1998), was to focus on the theoretical and observational aspects of microquasars. The study of microquasars, the sources in our Galaxy displaying powerful re lativistic jets, is a rapidly advancing field in astrophysics. The new instrumentation on ground (MERLIN, SCUBA, VLA, VLT) and aboard satellites (ASCA, BSAX, IS...
Brain Mapping: The Disorders
Brain Mapping: The Disorders is the first comprehensive text to describe the uses of the latest brain mapping technologies in the evaluation of patients with neurological, neurosurgical and psychiatric disorders. With contributions from the leading figures in the field, this heavily illustrated text is organized by disorders of brain systems, with specific examples of how one should use current neuroimaging techniques to evaluate patients with specific cerebral disorders. Comprehensive in scope, the text discusses patient evaluations using the wide range of modern magnetic resonance imaging techniques, positron emission tomography, single photon emission computed tomography, optical intrinsi...
The Jet Paradigm
The discovery of the ?rst case of superluminal radio jets in our galaxy in 1994 from the bright and peculiar X-ray source GRS 1915+105 has opened the way to a major shift in the direction of studies of stellar-mass accreting binaries. The past decade has seen an impressive increase in multi-wavelength studies. It is now known that all black hole binaries in our galaxy are radio sources and most likely their radio emission originates from a powerful jet. In addition to the spectacular events related to the ejection of superluminal jets, steady jets are known from many systems. Compared with their supermassive cousins, the nuclei of active galaxies, stellar-mass X-ray binaries have the advanta...
Disclosure
This text provides detailed coverage of the new rules of disclosure. Topics covered include documentary disclosure, non-documentary disclosure and specialist jurisdictions.
Dopamine Receptors and Transporters
"Details the function, characterization, and physiology of various dopamine receptor/transporter systems and explores their role in etiology, diagnosis, and disease management."
Pediatric Liver Transplantation
Written and edited by global leaders in the field, Pediatric Liver Transplantation: A Clinical Guide covers all aspects of treatment and management regarding this multifaceted procedure and unique patient population. This practical reference offers detailed, focused guidance in a highly templated, easy-to-consult format, covering everything from pre-transplantation preparation to surgical techniques to post-operative complications. - Provides an in-depth understanding of all aspects of pediatric liver transplantation, ideal for pediatric hepatologists, pediatric transplant surgeons, and others on the pediatric transplant team. - Covers all surgical techniques in detail, including split graft...
