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Stability of Drugs and Dosage Forms
Drug products are complex mixtures of drugs and excipients and, as such, their chemical and physical stability kinetics are complex. This book discusses the stability of these dosage forms with preformulation studies through to the studies on the final products. The book is intended for graduate students, researchers and professionals in the field of Pharmaceutics and Pharmaceutical Chemistry.
Prodrugs
These volumes represent a comprehensive guide to prodrugs. They guide the reader through the current status of the prodrug concept and its many applications and highlight its many successes in overcoming formulation and delivery of problematic drugs. Replete with examples of approved and marketed prodrugs, these volumes introduce the topic to the novice as well as professional in the design of prodrugs.
Chemical Stability of Pharmaceuticals
Provides a sound theoretical basis for understanding chemical kinetics and its uses in studying drug stability. Treats the calculations, approximations, and estimates that are useful to the pharmacist in professional practice, and presents a collection of selected drug-stability data from the pharmaceutical literature. This Handbook makes accessible to the pharmacist much of the information necessary to make pharmaceutical decisions about drug stability. Changes in this edition include thorough revision of the chapter on oxidation, addition of a new chapter on solid-state stability, and a tripling of the number of stability monographs. All monographs figures have been redrawn, most of them from published data, and all sources are cited.
Lymphatic Transport of Drugs
Lymphatic Transport of Drugs provides a thorough review of the determinants that affect the uptake and delivery of drugs and xenobiotics to the lymphatics. Factors affecting the transport and delivery of lipophilic drugs through the lymph after oral administration, lymphatic transport of polar drugs and macromolecules after gastrointestinal dosing, transport of drugs into the lymph after parenteral administration, and particulate drug delivery systems are among the topics examined in this volume. Lymphatic Transport of Drugs is primarily intended for pharmaceutical scientists who are attempting to alter the delivery of current therapeutic agents through formulation of prodrugs, as well as for researchers designing new drugs for lymph delivery.
Directed Drug Delivery
This book is based on the proceedings of the symposium entitled "Di rected Drug Delivery: A Multidisciplinary Problem," which was held in Lawrence, Kansas on October 17-19, 1984. The purpose of the sym posium and this book is to focus on the multidisciplinary nature of drug delivery. Development of a successful drug delivery system re quires contributions from various scientific disciplines, including pharmaceutical chemistry, analytical chemistry, medicinal chemistry, biochemistry, pharmacology, toxicology, and clinical medicine. The contents of this volume illustrate the importance of the various disci plines in identifying the problems and approaches for the develop ment of a rational and...
Current Catalog
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Preclinical Development Handbook
A clear, straightforward resource to guide you through preclinical drug development Following this book's step-by-step guidance, you can successfully initiate and complete critical phases of preclinical drug development. The book serves as a basic, comprehensive reference to prioritizing and optimizing leads, dose formulation, ADME, pharmacokinetics, modeling, and regulations. This authoritative, easy-to-use resource covers all the issues that need to be considered and provides detailed instructions for current methods and techniques. Each chapter is written by one or more leading experts in the field. These authors, representing the many disciplines involved in preclinical toxicology screen...
Handbook of Air Toxics
The Handbook of Air Toxics compiles, defines, and clarifies several methods and concepts of airborne toxic substances found in the environment. This comprehensive reference helps regulators, consultants, and other environmental professionals meet the challenges of sampling and analysis, emissions reductions, and health and safety issues related to human exposure. It is an important reference addressing the ongoing concern about the consequences of air pollution, and the implementation and modification of the Environmental Protection Agency's (EPA) Clean Air Act. Some of the methods described in the Handbook of Air Toxics include fluorescence, thermal desorption, selected ion monitoring, ion chromatography, light microscopy, specific electrode analysis, titration, colorimetry, atomic absorption, and spectrophotometry. It also covers the use of isokinetic sampling trains, midget impingers, carbon molecular sieves, and sampling canisters in the analysis of air toxics. The Handbook also contains recommendations from the EPA for analytical methods for those air toxics where methods do not already exist and provides advance information on future method development by the EPA.
The National Toxicology Program's Chemical Database
This database provides a vast amount of information about potentially toxic chemicals to regulatory and research agencies, consultants, academics, and libraries. The National Toxicology Program's Chemical Database consists of eight volumes containing 50 fields that present detailed information on 2,270 different chemicals. The data is obtained from the literature or experimentally determined. Each compound is listed in every volume even when there is no information available for it in some volumes. Information in the NTP database was gathered and updated as compounds were used throughout a 12 year period from 1979 to 1991. Throughout the eight volumes, the primary chemical name and the Chemi...
