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Angiogenesis, Lymphangiogenesis and Clinical Implications
Angiogenesis, the formation of new blood vessels, is fundamental for physiological processes such as embryonic and postnatal development, wound repair, and reproductive functions. Angiogenesis plays a major role in tumor growth and in several autoimmune and allergic disorders. Lymphangiogenesis, the formation of new lymphatic vessels, is also important for tumor growth, the formation of metastasis, and chronic inflammatory diseases. Judah Folkman, a pioneer in the study of angiogenesis, first proposed that macrophages and mast cells could be a relevant source of angiogenic factors. Since then, much effort has gone into the elucidation of the role of immune cells in the modulation of angiogen...
When Data Challenges Theory
This volume offers a critical appraisal of the tension between theory and empirical evidence in research on information structure. The relevance of ‘unexpected’ data taken into account in the last decades, such as the well-known case of non-focalizing cleft sentences in Germanic and Romance, has increasingly led us to give more weight to explanations involving inferential reasoning, discourse organization and speakers’ rhetorical strategies, thus moving away from ‘sentence-based’ perspectives. At the same time, this shift towards pragmatic complexity has introduced new challenges to well-established information-structural categories, such as Focus and Topic, to the point that some ...
Appraisal, Sentiment and Emotion Analysis in Political Discourse
This book adopts a multi-method multimodal approach to the study of online political communication, applying it to case studies from the UK, France, and Italy toward offering a portrait of the rapid ideological shifts in contemporary Western democracies. The volume introduces an integrated framework combining Sentiment and Emotion Analysis, rooted in lexical semantics, and the qualitative dimensions of Appraisal Theory, applying it to large corpora of online political communication from the UK, France, and Italy. Combei and Reggi highlight their combined potential in analyzing the multimodal resources in such discourses and in turn, revealing fresh insights into layers of subtext and the way...
