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Autism Spectrum Disorders: From Genotypes to Phenotypes
This Research Topic covers the pathogenetic processes in Autism Spectrum Disorder (ASD) that underpin the translation of genetic vulnerability to clinically significant symptoms. Available research data in ASD suggests that it is a neural connectivity disorder and that the social communication and related neurobehavioural symptoms result from reduced synchronization between key "social brain" regions. These interconnected neural systems can be understood through the relationship between functionally relevant anatomic areas and neurochemical pathways, the programming of which are genetically modulated during neurodevelopment and mediated through a range of epigenetic and environmental modulat...
Autism
The book covers some of the key research developments in autism and brings together the current state of evidence on the neurobiologic understanding of this intriguing disorder. The pathogenetic mechanisms are explored by contributors from diverse perspectives including genetics, neuroimaging, neuroanatomy, neurophysiology, neurochemistry, neuroimmunology, neuroendocrinology, functional organization of the brain and clinical applications from the role of diet to vaccines. It is hoped that understanding these interconnected neurobiological systems, the programming of which is genetically modulated during neurodevelopment and mediated through a range of neuropeptides and interacting neurotrans...
Where There Is No Child Psychiatrist
Mental health problems and worries are common among infants, children and adolescents in every part of the world. This book is a practical manual for primary healthcare professionals, teachers and anyone who works with children - especially in places where specialist psychiatric care is not available. After giving the reader an overview of child mental health problems, the manual goes on to deal with the various developmental, behavioural and emotional problems that arise in as many as 10% of the youth population. For each problem it first provides a case study and then describes how to find out more about a child with this problem. It suggests what can be done to help the child and their fa...
The Neurobiology and Genetics of Gilles de la Tourette Syndrome: New Avenues Through Large-Scale Collaborative Projects
Gilles de la Tourette Syndrome (TS) is a common, albeit severely under-diagnosed, neuropsychiatric disorder that is caused by a complex genetic basis, interacting with environmental factors. High comorbidity rates with other neurodevelopmental disorders such as attention deficit/hyperactivity disorder and obsessive compulsive disorder raise the intriguing hypothesis of a shared etiological background. Abnormalities of corticostriatal-thalamic-cortical circuits (CSTC) and dysfunction of both dopamine and serotonin neurotransmitter systems are assumed to be associated with TS. Recently, multiple lines of evidence also point towards an important role of additional neurotransmitters such as hist...
A Cursing Brain? The Histories of Tourette Syndrome
A Cursing Brain? traces the problematic classification of Tourette syndrome through three distinct but overlapping stories: the claims of medical knowledge, patients' experiences, and cultural expectations and assumptions.
Chasing Tourette’s: Time, Freedom, and the Missing Self
This book offers a philosophical perspective on contemporary Tourette Syndrome scholarship, a field which has exploded over the last thirty years. Despite intense research efforts on this common neurodevelopmental condition in the age of the brain sciences, the syndrome’s causes and potential cures remain intriguingly elusive. How does this lack of progress relate to the tacitly operating philosophical concepts that shape our current thinking about Tourette Syndrome? This book foregrounds these tacit concepts and shows how they relate to “big topics” in philosophy such as time, volition, and the self. By tracing how these topics relate to current research on Tourette’s, it invites us...
The Wiley Handbook of Developmental Psychopathology
The Wiley Handbook of Developmental Psychopathology offers a concise, up-to-date, and international overview of the study of developmental psychopathology. Examines the cognitive, neurobiological, genetic, and environmental influences on normal and abnormal development across the lifespan Incorporates methodology, theory, and the latest empirical research in a discussion of modern techniques for studying developmental psychopathology Considers the legal, societal, and policy impacts of changes to diagnostic categories in the light of the transition to DSM-5 Moves beyond a disorder-based discussion to address issues that cut across diagnostic categories
Emerging Illnesses and Society
"Presenting a theoretical model of the social process of "emerging" illness, the volume's introductory chapter identifies critical factors that shape different trajectories toward the construction of public health priorities. Through case studies of individual diseases and analyses of public awareness campaigns and institutional responses, later chapters provide important insights into the reasons why some illnesses receive more attention and funding than others."--Jacket.
