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New Non-opioid Analgesics: Understanding Molecular Mechanisms on the Basis of Patch-clamp and chemical Studies
The monograph is a summary of methods used to study pain receptors and the results obtained in some experiments designed to study the effect of non-opioid analgesics. The molecular mechanisms of nociceptive information control in primary sensory nociceptive neurons are described based on investigations of the membrane signaling cascade (opioid-like receptor → Na+,K+-ATPase → NaV1.8 channel) observed by the authors. Based on this data, the authors conclude that the modulation of NaV1.8 channels responsible for the coding of noxious signals can be carried out due to two novel targeting mechanisms. The first of these is the activation of opioid-like receptors; the second is the activation o...
Understanding Molecular Mechanisms on the Basis of Patch-clamp and Quantum-chemical Studies: New Non-opioid Analgesics
The monograph is a summary of methods used to study pain receptors and the results obtained in some experiments designed to study the effect of non-opioid analgesics. The molecular mechanisms of nociceptive information control in primary sensory nociceptive neurons are described based on investigations of the membrane signaling cascade (opioid-like receptor ? Na+,K+-ATPase ? NaV1.8 channel) observed by the authors. Based on this data, the authors conclude that the modulation of NaV1.8 channels responsible for the coding of noxious signals can be carried out due to two novel targeting mechanisms. The first of these is the activation of opioid-like receptors; the second is the activation of Na...
VIII International Scientific Siberian Transport Forum
This book presents the findings of scientific studies on the successful operation of complex transport infrastructures in regions with extreme climatic and geographical conditions. It features the proceedings of the VIII International Scientific Siberian Transport Forum, TransSiberia 2019, which was held in Novosibirsk, Russia, on May 22–27, 2019. The book discusses improving energy efficiency in the transportation sector and the use of artificial intelligence in transport, highlighting a range of topics, such as freight and logistics, freeway traffic modelling and control, intelligent transport systems and smart mobility, transport data and transport models, highway and railway construction and trucking on the Siberian ice roads. Consisting of 214 high-quality papers on a wide range of issues, these proceedings appeal to scientists, engineers, managers in the transport sector, and anyone involved in the construction and operation of transport infrastructure facilities.
The 21st Century from the Positions of Modern Science: Intellectual, Digital and Innovative Aspects
These proceedings gather the best papers presented at the “10th International Scientific and Practical Conference – the 21st Century from the Positions of Modern Science: Intellectual, Digital and Innovative Aspects,” which was organized by the non-profit organization “Institute of Scientific Communications.” The conference took place on May 23–24 in Nizhny Novgorod, Russia, with support from Minin Nizhny Novgorod State Pedagogical University. The chief advantage of these proceedings are their multidisciplinary character – they include articles and empirical studies addressing various fields, including economics, the social sciences, and law. Accordingly, the target audience is...
Artificial Intelligence: Anthropogenic Nature vs. Social Origin
This book presents advanced research studies on the topic of artificial intelligence as a component of social and economic relations and processes. It gathers research papers from the International Research-to-Practice Conference “The 21st Century from the Positions of Modern Science: Intellectual, Digital and Innovative Aspects” (May 23–24, 2019, Nizhny Novgorod, Russia) and the International Research-to-Practice Conference “Economics of Pleasure: a Science of Enjoying Economic Activities” (October 3–5, 2019, Prague, Czech Republic). Both conferences were organized by the Autonomous Non-Profit Organization “Institute of Scientific Communications” (Volgograd). What sets this ...
Ecotoxicology of Explosives
Managing sites contaminated with munitions constituents is an international challenge. Although the choice of approach and the use of Ecological Risk Assessment (ERA) tools may vary from country to country, the assurance of quality and the direction of ecotoxicological research are universally recognized as shared concerns. Drawing on a multidiscip
Adaptation Biology and Medicine
Although the entire evolution of life is an adaptation right from the coming-together of the elements and reaching to human life as we know today, the realization of the adaptation biology as a discipline is relatively recent. Furthermore, subcellular basis of gradual adaptation of body systems in stressful conditions is still a greate mystery of biology. The present book attempts to fill that gap. It is known that such an adaptation not only increases tolerance of the body to that given stress but also to other challenges. A complete knowledge of this cross protection needs to be defined and exp;oited to improve patient care. The book includes chapters describing subcellular adaptations; ad...
The Scavenger Door
From a Hugo Award-winning author comes the third book in this action-packed sci-fi caper, starring Fergus Ferguson, interstellar repo man and professional finder. Fergus is back on Earth at last, trying to figure out how to live a normal life. However, it seems the universe has other plans for him. When his cousin sends him off to help out a friend, Fergus accidently stumbles across a piece of an ancient alien artifact that some very powerful people seem to think means the entire solar system is in danger. And since he's the one who found it, they’re certain it’s also his problem to deal with. With the help of his newfound sister, friends both old and new, and some enemies, too, Fergus needs to find the rest of the artifact and destroy the pieces before anyone can reassemble the original and open a multidimensional door between Earth and a vast, implacable, alien swarm. Problem is, the pieces could be anywhere on Earth, and he’s not the only one out searching.
Finder
From Hugo Award-winning debut author Suzanne Palmer comes an action-packed sci-fi caper starring Fergus Ferguson, interstellar repo man and professional finder Fergus Ferguson has been called a lot of names: thief, con artist, repo man. He prefers the term finder. His latest job should be simple. Find the spacecraft Venetia's Sword and steal it back from Arum Gilger, ex-nobleman turned power-hungry trade boss. He’ll slip in, decode the ship’s compromised AI security, and get out of town, Sword in hand. Fergus locates both Gilger and the ship in the farthest corner of human-inhabited space, a backwater deep space colony called Cernee. But Fergus’ arrival at the colony is anything but si...
