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User-Friendly Tools Applied to Genetics or Systems Biology
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Transcriptomics in Health and Disease
The study of transcriptomics is key to understanding complex diseases. This new edition will build on the foundation of the first edition while incorporating the progress that has been made in the field of transcriptomics in the past six years, including bioinformatics for data analysis. Written by leading experts, chapters address new subjects such as methodological advances in large-scale sequencing, the sequencing of single-cells, and spatial transcriptomics. The new edition will address how transcriptomics may be used in combination with genetic strategies to identify causative genes in monogenic and complex genetic diseases. Coverage will also explore transcriptomics in challenging groups of diseases, such as cancer, inflammation, bacterial infection, and autoimmune diseases. The updated volume will be useful for geneticists, genome biologists, biomedical researchers, molecular biologists, bioinformaticians, and students, among others.
Drug Discovery for Leishmaniasis
Drug Discovery for Leishmaniasis aims to provide a perspective of the current treatments and their challenges, blended with the emerging strategies and methodologies that will drive new target appraisals and drug developments, as well as addressing the molecular basis of resistance in Leishmania.
Jessica Rainbow e a magia por trás do espetáculo
JESSICA CRESCEU no Circo Rainbow, no Lago Michigan, em Chicago. Descobriu em sua infância magias desconhecidas pelas pessoas, existentes em um jardim encantado, que ficava atrás do grandioso circo. Um universo repleto de cores e sonhos, do qual ela usufruía todos os dias e compartilhava em seus espetáculos. Ela aprendia de tudo, mas sua maior paixão sempre foi cantar. Porém, aos dezesseis anos, após o desaparecimento da mãe, Jessica não conseguiu mais vivenciar a magia do circo. Nessa mesma época, descobriu a Bossa Nova e decidiu aprender a língua portuguesa. Então, no início da década de 1960, aos dezoito anos, foge para o Rio de Janeiro, deixando apenas um bilhete ao seu pai. Na Cidade Maravilhosa, Jessica se depara com um mundo fabuloso, faz incríveis amizades e persegue o sonho de cantar. Apesar de sua vida estar tomando um rumo brilhante, o mundo mágico sai do eixo com a possibilidade da venda do circo para a Madame Gaga. Agora ela terá de realizar seus sonhos ao mesmo tempo em que precisa salvar a magia do universo.
Open Praxis, Open Access
Many in the world of scholarship share the conviction that open access will be the engine of transformation leading to more culture, more research, more discovery, and more solutions to small and big problems. This collection brings together librarians, scholars, practitioners, policymakers, and thinkers to take measure of the open access movement. The editors meld critical essays, research, and case studies to offer an authoritative exploration of the concept of openness in scholarship, with an overview of how it is evolving in the US, Canada, Europe, and Asia; open access publishing, including funding models and the future of library science journals; the state of institutional repositories; Open Educational Resources (OER) at universities and a consortium, in subject areas ranging from literary studies to textbooks; and open science, open data, and a pilot data catalog for raising the visibility of protected data.
Gene Prediction
This volume introduces software used for gene prediction with focus on eukaryotic genomes. The chapters in this book describe software and web server usage as applied in common use-cases, and explain ways to simplify re-annotation of long available genome assemblies. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary computational requirements, step-by-step, readily reproducible computational protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Gene Prediction: Methods and Protocols is a valuable resource for researchers and research groups working on the assembly and annotation of single species or small groups of species. Chapter 3 is available open access under a CC BY 4.0 license via link.springer.com.
Computational Non-coding RNA Biology
Computational Non-coding RNA Biology is a resource for the computation of non-coding RNAs. The book covers computational methods for the identification and quantification of non-coding RNAs, including miRNAs, tasiRNAs, phasiRNAs, lariat originated circRNAs and back-spliced circRNAs, the identification of miRNA/siRNA targets, and the identification of mutations and editing sites in miRNAs. The book introduces basic ideas of computational methods, along with their detailed computational steps, a critical component in the development of high throughput sequencing technologies for identifying different classes of non-coding RNAs and predicting the possible functions of these molecules. Finding, ...
User-Friendly Tools Applied to Genetics Or Systems Biology
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Plant Circular RNAs
This volume presents readers with up-to-date protocols, bioinformatics toolkits, and reference material for understanding circRNAs in plants. The chapters in this book summarize the concepts and techniques for prediction/identification, validation, and analysis of plant circRNAs and their regulatory targets. Some of the topics covered are procedures for circRNA identification and characterization; strategies for circRNA generation; next generation sequencing (NGS) technologies and circRNAs’ research; and bioinformatics tools and pipelines for the analysis of circRNA-miRNA-mRNA regulatory networks. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Plant Circular RNAs: Methods and Protocols is an important reference for any researcher looking to explore and apply the latest developments made in this field.
