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Canine lymphoma is the most common hematopoietic neoplasm in dogs, arising from monoclonal expansion of B lymphocytes, T lymphocytes, or null cells (non-B and non-T, natural killer cells - NK). It might originate in any area of the body and its most striking feature is its heterogeneity, accounting for more than 30 different subtypes. Novel entities have recently been described and characterized in canine medicine, such as diffuse small B-cell lymphoma and small cell T cell intestinal lymphoma, to list a few. Despite extensive studies, recent progression in therapeutical approaches and improved outcomes, relapse or recurrence remain a common problem with conventional therapy for intermediate...
Comprehensive look into the dangerous world of glider warfare.
Questo libro racconta la storia del paese di Daverio fra il 900 e il 2000, un racconto straordiariamente lucido e preciso, che permette di comprendere la storia un tipico paese varesino a cavallo del millennio. Attraverso il racconto delle esperienze personali, otteniamo in ritratto molto vivo del secolo appena trascorso, nelle pagine rivivono le persone che hanno dato vita al passato e un pò anche al presente del Paese di Daverio. Pur essendo un libro riguardante la vita di un paese è leggibile e godibile senza problemi anche da chiunque voglia avere un ritratto sociale di una cittadina varesina fra le due Guerre Mondiali ed oggi.
Written by internationally recognized leaders in Heparanase biology, the book’s eight chapters offer an opportunity for scientists, clinicians and advanced students in cell biology, tumor biology and oncology to obtain a comprehensive understanding of Heparanase’s multifaceted activities in cancer, inflammation, diabetes and other diseases, as well as its related clinical applications. Proteases and their involvement in cancer progression have been well addressed and documented; however, the emerging premise presented within this book is that Heparanase is a master regulator of aggressive cancer phenotypes and crosstalk with the tumor microenvironment. This endoglycosidase contributes to...