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Fish Development and Genetics
The zebrafish is the most important fish model in developmental andgenetic analyses. This book contains 19 review articles covering abroad spectrum of topics, from development to genetic tools. Thecontents range from early development, the role of maternal factorsand gastrulation, to tissue differentiation and organogenesis, such asdevelopment of the organizer, notochord, floor plate, nervous system, somites, muscle, skeleton and endoderm
Live Imaging in Zebrafish
The zebrafish embryo has now been well established as an organism of choice for the genetic and cell biological basis of vertebrate development. Large-scale forward genetic screens together with reverse genetic tools have resulted in a flood of new information on the regulation of vertebrate development. Furthermore, the unique transparency of the zebrafish embryo allows unprecedented access to cells and tissues and many important discoveries on gene function have already been made using live imaging techniques in this organism. This book successfully brings together state-of-the-art methodologies of live imaging, such as the use of fluorescence correlation spectroscopy (FCS), that will be u...
Fluorescent Proteins II
Fluorescent proteins are intimately connected to research in the life sciences. Tagging of gene products with fluorescent proteins has revolutionized all areas of biosciences, ranging from fundamental biochemistry to clinical oncology, to environmental research. The discovery of the Green Fluorescent Protein, its first, seminal application and the ingenious development of a broad palette of fluorescence proteins of other colours, was consequently recognised with the Nobel Prize for Chemistry in 2008. Fluorescent Proteins II highlights the physicochemical and biophysical aspects of fluorescent protein technology beyond imaging. It is tailored to meet the needs of physicists, chemists and biologists who are interested in the fundamental properties of fluorescent proteins, while also focussing on specific applications. The implementations described are cutting-edge studies and exemplify how the physical and chemical properties of fluorescent proteins can stimulate novel findings in life sciences.
Asian Biotech
Providing the first overview of Asia’s emerging biosciences landscape, this timely and important collection brings together ethnographic case studies on biotech endeavors such as genetically modified foods in China, clinical trials in India, blood collection in Singapore and China, and stem-cell research in Singapore, South Korea, and Taiwan. While biotech policies and projects vary by country, the contributors identify a significant trend toward state entrepreneurialism in biotechnology, and they highlight the ways that political thinking and ethical reasoning are converging around the biosciences. As ascendant nations in a region of postcolonial emergence, with an “uncanny surplus” i...
Zic family
This book provides a comprehensive overview of ZIC-family research. Part1 summarizes the ZIC family in animal evolution and development and presents an overall picture of the ZIC family gene structure in eumetazoan animals, providing an evolutionary hypothesis and reviewing the studies on the role of ZIC family proteins in developmental processes for each animal model. Part 2 shows that the ZIC family are the causative genes for developmental disorders, and discusses the role of the ZIC family in stem cell biology. It also presents studies on the ZIC family in the medical biology field. This interdisciplinary book is a valuable resource not only for those people directly involved in ZIC-family-related research, but also researchers in diverse research fields who are interested in the latest advances in biology and medicine.
Good Science
An examination of a decade and a half of political controversy, ethical debate, and scientific progress in stem cell research. After a decade and a half, human pluripotent stem cell research has been normalized. There may be no consensus on the status of the embryo—only a tacit agreement to disagree—but the debate now takes place in a context in which human stem cell research and related technologies already exist. In this book, Charis Thompson investigates the evolution of the controversy over human pluripotent stem cell research in the United States and proposes a new ethical approach for “good science.” Thompson traces political, ethical, and scientific developments that came toge...
Measuring the Impact of Peacebuilding Interventions on Rule of Law and Security Institutions
Since the 1990s, internationally-supported peacebuilding interventions have become increasingly prominent. Activities focusing on rule of law and security institutions are a key component of this agenda. Despite increasing calls for more rigorous analysis of the impact of peacebuilding interventions, conceptual advances have been limited. There is little clarity on what is working, what is not, and why. This SSR Paper seeks to address this gap by mapping relevant approaches and methodologies to measuring impact. It examines how international actors have approached these questions in relation to support to rule of law and security institutions in complex peacebuilding environments. Most significantly, the paper demonstrates that measuring impact is not only feasible but necessary in order to maximise the effectiveness of major international investments in this field.
KGB
Mikhail Gorbachev was hailed as the herald of a new era of international cooperation. This uncompromising book argues that Gorbachev might not have been as revolutionary as we would like to believe. The authors show how Soviet foreign policy in fact stemmed from the leaders' struggle for internal power--and therefore how the KGB's operations abroad were afforded the highest priority. The true function of the organization was to keep the Party in power, whatever the human cost. It is estimated that while the population of the USSR only doubled between 1905 and 1990, the repressive apparatus of the KGB increased eightfold. Whereas other books on the KGB emphasize its subversive role in foreign countries, this book, uniquely written from an insider's viewpoint, focuses on its dominant role within the Soviet system. In the most comprehensive and authoritative survey of the activities of the KGB to date, the authors look back to its founding in 1917, and also put recent events in perspective. Most importantly, they provide sound guidelines by which Western observers can distinguish fundamental from superficial change.--Adapted from jacket.
