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The Many Faces of Osteoarthritis
Osteoarthritis is the most common joint pathology which primarily affects the older population. The disease is characterized by unique pathological changes in some synovial joints, predominantly affecting the articular cartilage, but also entire joints, including the synovial tissue and subchondral bone. The remarkable growth of research on normal and abnormal biology of tissues in the articulating joint, including the application of novel molecular biological approaches and new imaging techniques, is reflected in this volume. It describes the current state of knowledge and helps to further understand the etiopathology of osteoarthritis, hopefully leading to early detection of the disease and novel treatment modalities. The volume contains contributions and discussions from a select group of investigators, all experts in this field, who met at the conference "The Many Faces of Osteoarthritis", held in June 2001 at Lake Tahoe, to acknowledge Klaus E. Kuettner and his contributions to osteoarthritis...
Integrated Pest and Disease Management in Greenhouse Crops
This book represents a new, completely updated, version of a book edited by two of the current editors, published with Springer in 1999. It covers pest and disease management of greenhouse crops, providing readers the basic strategies and tactics of integrated control together with its implementation in practice, with case studies with selected crops. The diversity of editors and authors provides readers a complete picture of the world situation of IPM in greenhouse crops.
Functional Plant Genomics
The openings offered by functional genomics reconciles organism biology and molecular biology, in order to define an integrative biology that should allow new insights about how a phenotype is built up from a genotype in interaction with its environment. This book covers a wide area of concepts and methods in genomics. This range from international
Genomic Designing of Climate-Smart Vegetable Crops
This book reviews modern strategies in the breeding of vegetables in the era of global warming. Agriculture is facing numerous challenges in the 21st century, as it has to address food, nutritional, energy and environmental security. Future vegetable varieties must be adaptive to the varying scenarios of climate change, produce higher yields of high- quality food and feed and have multiple uses. To achieve these goals, it is imperative to employ modern tools of molecular breeding, genetic engineering and genomics for ‘precise’ plant breeding to produce ‘designed’ vegetable varieties adaptive to climate change. This book is of interest to scientists working in the fields of plant genetics, genomics, breeding, biotechnology, and in the disciplines of agronomy and horticulture.
Genomics of Plant-Associated Fungi and Oomycetes: Dicot Pathogens
This book describes how genomics has revolutionized our understanding of agriculturally important plant-associated fungi and oomycetes. It illustrates some fundamental discoveries about these eukaryotic microbes with regard to the overall structure of their genomes, their lifestyles and the molecular mechanisms that form the basis of their interactions with plants. Genomics has provided new insights into fungal lifestyles and led to practical advances in plant breeding and crop protection, such as predictions about the spread and evolution of new pathogens. This volume focuses on fungi and oomycetes that are typical dicot plant pathogens and includes: Sclerotinia sclerotiorum, Botrytis cinerea, Alternaria sp.,Verticillium alfalfae and Verticillium dahliae, Fusarium oxysporum, Phytophthora capsici, Phytophthora sojae, Phytophthora ramorum, Phytophthora infestans, Hyaloperonospora arabidopsidis.
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Osteogenesis
This book provides an in-depth overview of current knowledge about Osteogenesis, including molecular mechanisms, transcriptional regulators, scaffolds, cell biology, mechanical stimuli, vascularization and osteogenesis related diseases. Hopefully, the publication of this book will help researchers in this field to decide where to focus their future efforts, and provide an overview for surgeons and clinicians who wish to be directed in the developments related to this fascinating subject.
Chondrocytes
This detailed book collects a variety of methods from investigators at the forefront of chondrocyte biology and pathology research that they have tailored for their research projects in order to tackle the unique properties and challenges of the chondrocyte and those of its tissue matrix. Divided into three parts, the volume explores experimental models to study chondrocytes, in vivo assays, as well as methods to characterize the chondrocyte phenotype with high-throughput or discrete assays on cells maintained in vivo, just isolated from their tissue (ex vivo), or cultured in vitro. Written in the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Chondrocytes: Methods and Protocols is an ideal guide for experts as well as newcomers in the cartilage field with the aim of sparking new research ideas in order to solve many of the pending mysteries regarding cartilage biology, disease mechanisms, and potential treatments.
Surviving Hypoxia
Surviving Hypoxia: Mechanisms of Control and Adaptation is a synthesis of findings and thoughts concerning hypoxia. The thermodynamics of hypoxia are discussed in detail, including acid-base balance and self-pollution resulting from the accumulation of anaerobic end-products. The book focuses on descriptions and discussions of common facets, contrasting solutions in a variety of physiological hypoxia defense strategies, including those shown by plants, invertebrates, and vertebrates. Special treatment is given to the distinctive problems that hypoxia presents to vulnerable organs such as the kidney, liver, and brain. It also addresses pathological events in addition to protective mechanisms. Clinical implications of basic research are examined in the book, which provides new insights into underlying pathological processes occuring in hypoxic-induced organ failure and indicates new paths for successful clinical intervention. Surviving Hypoxia: Mechanisms of Control and Adaptation is an excellent reference for all researchers interested in the physiological effects of hypoxia, underlying pathological events, and protective mechanisms.
