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The volume contains the main papers presented at the 1994 EUROTOX Congress, Basel, Switzerland, August 21-24, 1994. Toxicology has become a less descriptive science because more importance has been placed on the mechanisms underlying toxic effects. This is reflected in symposia and workshops devoted to species differences in organ toxicity, receptor-mediated toxicity and stereochemical effects of xenobiotics. Recent progress in the fields of immunotoxicology, ecotoxicology, and neurotoxicology is highlighted and documented together with the present discussion on harmonized regulatory guidelines.
This book describes the crucial scientific interface between central neurotransmitter regulation and interacting hormonal pathways. It provides a review of the previously published literature on neuroendocrine mechanisms and brings the reader up-to-date with the latest developments in the field. Chapters cover the following areas: -- cellular interactions of neurotransmitters to induce specific release of a peptide hormone -- the role of opioids in the regulation of reproductive hormones and the possible implication of endorphins and enkephalins in developmental endocrinology -- immunohistochemical localization of vasoactive intestinal polypeptide as a tool to distinguish the possible role of the peripheral nervous system from that of central nervous control in stress and pathological situations -- developmental endocrinology and neurohormonal control of the ovarian cycle.
This volume marks the end of twenty years of neurosecretion during which there were five symposia, namely Naples (1953), Lund (1957), Bristol (1961), Strasbourg (1966), and Kiel (1970). In comparison with these symposia an exceptionally large number of papers were read at this the sixth symposium, in London, and for economic reasons it has not been possible to publish all the papers in extenso. The editors have therefore been obliged to undertake the unenviable work of selection, a task made all the more difficult by the excel lence and importance of contributions of the symposium. We felt that it was of the utmost importance at this moment in the history of neurosecretion to present as comp...
Biochemical Basis of Functional Neuroteratology
Despite rapidly increasing interest in developmental immunotoxicology, there is not yet a textbook focused on this hot area of research. Developmental Immunotoxicology fills the void with overviews of immune system development in experimental animal and human models, and discusses the complex issues related to the evolution of developmental immunology and risk assessment. This text describes different models used to study developmental immunotoxicology and examples of specific developmental immunotoxic agents, including therapeutics. The text concludes with several chapters that describe the role of neuroimmune interactions as they relate to developmental immunotoxicology. Using a didactic approach, Developmental Immunotoxicology provides an explanatory overview of this cutting-edge field for toxicologists, immunologists, and developmental biologists. It provides a lucid account of this area of research-proposing answers to some questions and stimulating debate on those questions yet to be addressed by the research community.
Mechanisms of Synaptic Transmission
Fundamental Toxicology is a concise and comprehensive review of toxicology. It is based on the highly successful Fundamental Toxicology for Chemists and has been enriched and expanded. Every chapter in this new edition has been revised and updated, and four new chapters have been added. With contributions from internationally recognised experts in their field, this broad-based introduction to the topic covers both well-established and rapidly developing areas of toxicology, such as toxicogenomics, reproductive toxicology, behavioural toxicology and ecotoxicology. The book was written and published with the support of the International Union of Pure and Applied Chemistry (IUPAC). The book inc...
This consistent and well-illustrated text is an up-to-date survey of cellular and molecular events contributing to the assembly of the vertebrate nervous system. Chapters include a mixture of historical content and descriptions from literature that best illustrate specific aspects of development.
Veterinary Toxicology, 2nd edition is a unique single reference that teaches the basic principles of veterinary toxicology and builds upon these principles to offer an essential clinical resource for those practicing in the field. This reference book is thoroughly updated with new chapters and the latest coverage of topics that are essential to research veterinary toxicologists, students, professors, clinicians and environmentalists. Key areas include melamine and cyanuric acid, toxicogenomics, veterinary medical geology, toxic gases, toxicity and safety evaluation of new veterinary pharmaceuticals and much more. The 2nd edition of this popular book represents the collective wisdom of leadin...