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Cancer Genome and Tumor Microenvironment
Oncogenes and tumor suppressor genes had been traditionally studied in the context of cell proliferation, differentiation, senescence, and survival, four relatively cell-autonomous processes. Consequently, in the late ’80s-early ’90s, neoplastic growth was described largely as an imbalance between net cell accumulation and loss, brought about through mutations in cancer genes. In the last ten years, a more holistic understanding of cancer has slowly emerged, stressing the importance of interactions between neoplastic and various stromal components: extracellular matrix, basement membranes, fibroblasts, endothelial cells of blood and lymphatic vessels, tumor-infiltrating lymphocytes, etc. The commonly held view is that changes in tumor microenvironment are “soft-wired”, i.e., epigenetic in nature and often reversible. Yet, there exists a large body of evidence suggesting that well-known mutations in cancer genes profoundly affect tumor milieu. In fact, these non-cell-autonomous changes might be one of the primary reasons such mutations are preserved in late-stage tumors.
Government Control of the Press in Modern China, 1900–1949
A pioneering study of government control of the press in Modern China, including censorship, bribery, and intimidation, in the first half of the twentieth century. Includes documentation of numerous cases of press persecution by various regimes, including the late Ch'ing dynasty, the Peking government and warlord years, the Nationalist government's Nanking decade, and the war of resistance against the Japanese and postwar periods..
Skin Stem Cells
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