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Cancer and inflammatory diseases research: from the basics to the precision medicine
Precision medicine, or personalized medicine, is related to treatment based on the patient’s individual characteristics. To promote this personalized approach, diseases must accurately be diagnosed; specific biomarkers can predict disease evolution and optimize therapy based on each patient's characteristics such as their genetic background, lifestyle and environmental risk factors. Over the years, we have seen a revolution in pharmacotherapy and management of patients receiving personalized medicine, especially when we consider immunotherapy and specific tyrosine kinases inhibitors. Patients with inflammatory diseases, such as monogenetic diabetes and chronic kidney disease, have benefited from the progress made within the last decade related to our understanding of the genetic basis of diabetes. Similarly, patients in precision oncology, with breast, prostate and blood cancer have experienced better overall survival rates with targeted therapy such as trastuzumab (breast cancer), PARPs inhibitors (prostate cancer), imatinib, ibrutinib and venetoclax (leukemia).
Mild Cognitive Impairment
Mild Cognitive Impairment (MCI) has been identified as an important clinical transition between normal aging and the early stages of Alzheimer's disease (AD). Since treatments for AD are most likely to be most effective early in the course of the disease, MCI has become a topic of great importance and has been investigated in different populations of interest in many countries. This book brings together these differing perspectives on MCI for the first time. This volume provides a comprehensive resource for clinicians, researchers, and students involved in the study, diagnosis, treatment, and rehabilitation of people with MCI. Clinical investigators initially defined mild cognitive impairmen...
Privileged Scaffolds in Medicinal Chemistry
This book addresses the various classes of privileged scaffolds and covers the history of their discovery and use.
Pharmacokinetics of Drugs
A compilation of researchers' experience in the areas of bioanalysis, pharmacokinetics, and drug metabolism, to present an up-to-date and comprehensive treatise on the application of these and related technologies in drug discovery, development, and clinical use. Contents cover descriptions of analytical methods, in vitro metabolism technology and membrane transport, reappraisal of classical pharmacokinetic problems, and the time course of drug action. The book concludes with a description of PET and imaging methods in pharmacokinetics and an appendix containing a critical appraisal of computer methods and pharmacokinetic software available for PCs.
Eating and Healing
Discover neglected wild food sourcesthat can also be used as medicine! The long-standing notion of food as medicine, medicine as food, can be traced back to Hippocrates. Eating and Healing: Traditional Food As Medicine is a global overview of wild and semi-domesticated foods and their use as medicine in traditional s
Chemical Biology
This volume seeks to enable the discovery of tools in chemical biology by providing readers with various techniques ranging from initial chemical genetic screening to target identification. To successfully highlight the essential components of the chemical biology tool discovery process, the book is organizes into four parts that focus on platforms for molecular discovery in in vitro cellular systems, in vivo chemical genetic screening protocols, and methods used to discover functional protein targets. Written in the highly successful Methods of Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Practical and informative, Chemical Biology: Methods and Protocols seeks to improve the success rate of the chemical biology field through the dissemination of detailed and experiential knowledge.
Drug Efflux Pumps in Cancer Resistance Pathways: From Molecular Recognition and Characterization to Possible Inhibition Strategies in Chemotherapy
Drug Efflux Pumps in Cancer Resistance Pathways: From Molecular Recognition and Characterization to Possible Inhibition Strategies in Chemotherapy, Volume Seven, describes the fundamental aspects of efflux pumps of the ATP-binding cassette superfamily in cancer resistance pathways, along with strategies to target and improve chemotherapy efficacy. Pumps of the ATP-binding cassette superfamily (ABCs) regulate the access of drugs to the intracellular space. In this context, the overexpression of ABCs is a well-known mechanism of multidrug resistance in cancer and is associated with therapeutic failure. Cancer types discussed include breast, endocrine, hematologic, gastrointestinal, musculoskeletal, lung, skin and central nervous system cancers. The book is a valuable source for researchers and advanced students in cancer, biology, pharmacology, pharmaceutical sciences, biomaterials and medical/clinical sciences that are interested in accessing a comprehensive compendium on efflux pumps in mechanisms of cancer resistance.
