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Retinal Degenerative Diseases
This book will contain the proceedings of the XIV International Symposium on Retinal Degeneration (RD2010), held July 13-17, 2010, in Mont-Tremblant, Quebec, Canada. The volume will present representative state-of-the-art research in almost all areas of retinal degenerations, ranging from cytopathologic, physiologic, diagnostic and clinical aspects; animal models; mechanisms of cell death; candidate genes, cloning, mapping and other aspects of molecular genetics; and developing potential therapeutic measures such as gene therapy and neuroprotective agents for potential pharmaceutical therapy.
Retinal Degenerative Diseases
Contains the proceedings of the XVI International Symposium on Retinal Degeneration (RD2014), to be held July 13-18, 2014 at the Asilomar Conference Center in Pacific Grove, California. A majority of those who will speak and present posters at the meeting will contribute to this volume. The Symposium addresses the blinding diseases of inherited retinal degenerations, which have no effective treatments and age-related macular degeneration, which has no cures, despite the fact that it is an epidemic among the elderly, with 1 in 3-4 affected by the age of 75. The RD2014 Symposium will focus on the exciting new developments aimed at understanding these diseases and providing therapies for them. ...
Ancient DNA
Ancient DNA refers to DNA which can be recovered and analyzed from clinical, museum, archaeological and paleontological specimens. Ancient DNA ranges in age from less than 100 years to tens of millions of years. The study of ancient DNA is a young field, but it has been revolutionized by the application of polymerase chain reaction technology, and interest is growing very rapidly. Fields as diverse as evolution, anthropology, medicine, agriculture, and even law enforcement have quickly found applications in the recovery of ancient DNA. This book contains contributions from many of the "first generation" researchers who pioneered the development and application of ancient DNA methods. Their c...
mechanistic studies of DNA replication and genetic recombination
Mechanistic Studies of DNA Replication and Genetic Recombination emerged from a symposium on DNA replication and genetic recombination held from March 16-21, 1980 in Keystone, Colorado. The event featured 30 plenary session talks, 13 workshop discussion groups, and the 210 poster sessions. The studies described in this book are paving the way for the elucidation of other basic genetic mechanisms, including ""new"" areas in molecular genetics such as those of eukaryotic gene expression and the transposition of mobile genetic elements. This book is divided into 10 parts: summaries of workshop discussion groups (Part I); studies on eukaryotic model systems for DNA replication (Part II); studies on bacterial replication origins (Part III); studies on replication origins of bacterial phages and plasmids (Part IV); studies on eukaryotic replication origins (Part V); studies on prokaryotic replication enzymology (Part VI); studies on eukaryotic replication enzymology (Part VII); studies on the fidelity of DNA replication (Part VIII); studies on DNA topoisomerases (Part IX); and studies of genetic recombination mechanisms (Part X).
Ocular Angiogenesis
Leading academic and pharmaceutical researchers and clinicians from many disciplines synthesize and summarize current clinical and basic knowledge concerning abnormal growth of blood vessels in the eye, the cause of major neovascular eye diseases. The authors also identify and assess the most promising approaches with potential for commercial exploitation and discuss the challenges encountered in developing therapeutics for ocular neovascular diseases. Highlights include illuminating chapters on gene therapy and novel drug delivery systems and excellent summaries of the newest therapeutic approaches.
Ribozymes and siRNA protocols
In this completely updated and expanded edition of a classic bench manual, hands-on experts take advantage of the latest advances in ribozyme, DNAzyme, hammerhead ribozymes and derivatives, and RNA interference technologies to describe in detail the exciting and successful methods now available for gene inactivation in vitro and in vivo. Their optimized techniques employ hairpin ribozymes, DNAzymes, hammerhead ribozymes and derivatives, group I intron ribozymes, RNase P ribozymes, and siRNAs, as well as general methods for RNA structure analysis, delivery of oligonucleotides, and gene therapy. Also provided are novel methods for identifying accessible cellular mRNA sites; group I intron and ...
Recent Advances In Retinal Degeneration
The product of perhaps the most important research meeting in the field, this essential text outlines all the latest research in retinal degeneration. Culled from the proceedings of the International Symposium on the subject, the topics in this volume explore the etiology, cellular mechanisms, epidemiology, models and potential therapeutic measures for the blinding diseases of retinitis pigmentosa and age-related macular degeneration. A must-read for researchers in the field.
Retinal Degenerative Diseases
Retinal Degenerations is the result of the International Symposium on Retinal degeneration which has become perhaps the most important research meeting in the field. THe topics in this volume explore the etiology, cellular mechanisms, epidemiology, genetics, models and potential therapeutic measures for the blinding diseases of retinitis pigmentosa and age-related macular degeneration.
The Parvoviruses
The Parvoviridae have been of increasing interest to reseachers in the past decade. Their small size and simple structure have made them ame nable to detailed physiochemical analysis, and from this work relatively detailed information has resulted that has signficantly increased our un derstanding of the biology of these viruses. It has become clear that the Parvoviridae are of interest not only for their own sake, but also because their relative simplicity renders them useful probes in the study of the biology of host cells and of other DNA viruses with which they interact. The Dependovirus genus, for instance, contains the defective adeno-as sociated viruses (AA V), which require a coinfec...
