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Contemporary Accounts in Drug Discovery and Development
CONTEMPORARY ACCOUNTS IN DRUG DISCOVERY AND DEVELOPMENT A useful guide for medicinal chemists and pharmaceutical scientists Drug discovery is a lengthy and complex process that typically involves identifying an unmet medical need, determining a biological target, chemical library screening to identify a lead, chemical optimization, preclinical studies and clinical trials. This process often takes many years to complete, and relies on practitioners’ knowledge of chemistry and biology, but also—and perhaps more importantly—on experience. Improving the success rate in discovery and development through a thorough knowledge of drug discovery principles and advances in technology is critical...
Case Studies in Modern Drug Discovery and Development
Learn why some drug discovery and development efforts succeed . . . and others fail Written by international experts in drug discovery and development, this book sets forth carefully researched and analyzed case studies of both successful and failed drug discovery and development efforts, enabling medicinal chemists and pharmaceutical scientists to learn from actual examples. Each case study focuses on a particular drug and therapeutic target, guiding readers through the drug discovery and development process, including drug design rationale, structure-activity relationships, pharmacology, drug metabolism, biology, and clinical studies. Case Studies in Modern Drug Discovery and Development b...
Fuzzy Systems, Knowledge Discovery and Natural Computation Symposium
The Fuzzy Systems, Knowledge Discovery, and Natural Computation Symposium (FSKDNC 2013) was successfully held from 24 to 25 July 2013, in Shenyang, China. The Symposium was a platform for authors to present their recent development on fuzzy systems, knowledge discovery, and natural computation (i.e., intelligent techniques inspired from nature, such as neural networks, genetic algorithms, and particle swarm optimization). The Symposium attracted numerous submissions from around the globe. Each submitted paper was rigorously reviewed by the program committee and additional reviewers based on originality, significance and quality of the research, clarity of the presentation, and relevance to the Symposium theme. 60 papers are included in the Symposium proceedings after the review process. The great efforts of the authors, the Organizing Committee members, the Program Committee members, and the additional reviewers are acknowledged here. The Symposium would not have been possible without the support from Liaoning Technical University. The professional and courteous staff from DEStech Publications, Inc also deserves special credits.
Case Studies in Modern Drug Discovery and Development
Learn why some drug discovery and development efforts succeed . . . and others fail Written by international experts in drug discovery and development, this book sets forth carefully researched and analyzed case studies of both successful and failed drug discovery and development efforts, enabling medicinal chemists and pharmaceutical scientists to learn from actual examples. Each case study focuses on a particular drug and therapeutic target, guiding readers through the drug discovery and development process, including drug design rationale, structure-activity relationships, pharmacology, drug metabolism, biology, and clinical studies. Case Studies in Modern Drug Discovery and Development b...
Labor’s Share of Income
This book analyzes the decrease in labor share in China, which is a ratio of national income distribution to capital at three different levels (macro, meso, and micro) and from three different perspectives (growth, transition and opening up). The worsening income distribution has been a key issue for both Chinese and global economies in recent decades. The book shows that the decrease in labor share is closely related to economic growth, increasing extent of globalization, and firms with heterogeneous characteristics. Moreover, the book explains income inequality in detail, focusing on China’s increasingly important and emerging economy.
Directory of Graduate Research
Faculties, publications and doctoral theses in departments or divisions of chemistry, chemical engineering, biochemistry and pharmaceutical and/or medicinal chemistry at universities in the United States and Canada.
Collected Papers on Collaborative Enterprise Architecture in China
This book includes: Entry, withdrawal and dynamic sequential decision of China's export enterprises by YE Ninghua, BAO Qun, ZHANG Bowei; Has China realized the quality-driven growth in the ICT exports- an empirical study based on the ternary analysis and gravity model by LIU Yao, DING Yan; China's demographic estimation by using the generalized stable population model by CHEN Wei; Effects of transnational mergers and acquisitions on the competitiveness of domestic enterprises: an empirical analysis of the Chinese manufacturing sector by YE Shenghong, WANG Kaiyu, SUN Yiping; The optimal space of China's industrial policy: subsidy effects, compatible competition and overcapacity by HUANG Xianhai, SONG Xueyin, ZHU Zhujun; Impact of product market competition on corporate cash flow risk analysis based on the competition degree of industry and the competitive position of enterprises by LOU Fan, LI Xiaojian, CHEN Xiaoyan.
Scientific Report
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Comprehensive Medicinal Chemistry III
Comprehensive Medicinal Chemistry III, Eight Volume Set provides a contemporary and forward-looking critical analysis and summary of recent developments, emerging trends, and recently identified new areas where medicinal chemistry is having an impact. The discipline of medicinal chemistry continues to evolve as it adapts to new opportunities and strives to solve new challenges. These include drug targeting, biomolecular therapeutics, development of chemical biology tools, data collection and analysis, in silico models as predictors for biological properties, identification and validation of new targets, approaches to quantify target engagement, new methods for synthesis of drug candidates such as green chemistry, development of novel scaffolds for drug discovery, and the role of regulatory agencies in drug discovery. Reviews the strategies, technologies, principles, and applications of modern medicinal chemistry Provides a global and current perspective of today's drug discovery process and discusses the major therapeutic classes and targets Includes a unique collection of case studies and personal assays reviewing the discovery and development of key drugs
