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Immune Responses Against Tumors - From the Bench to the Bedside
Traditionally, surgery, radiotherapy, chemotherapy and hormonal therapy have been used in clinical practice to treat cancer patients. However, these methods are either not completely tumor free or without collateral damage to health tissues. Therefore, tumor recurrence, partial remission, treatment side effect and poor tolerance in elderly patients, and lack of effective strategy to treat late-stage cancers have been the major hurdles faced by clinicians in health care. Although cancer immunotherapy including checkpoint blockade, CAR-T, oncolytic viruses, and recombinant cytokines has taken center stage in mainstream oncology because of its specifically targeting tumor cells without affecting surrounding normal cells, only a proportion of patients receiving treatment respond and others relapse after an initial response. Different tumor indications respond differently, and even in cancer types that respond, unresponsiveness are still observed. This resistance suggests that either lack of sufficient host recognition and immunity (intrinsic) or active immune suppression by tumor complex (acquired).
Diplomatic List
Directory of foreign diplomatic officers in Washington.
Progress in Olefin Polymerization Catalysts and Polyolefin Materials
The First Asian Polyolefin Workshop introduces the recent developments and the research activities on polyolefin technology in Asia, which is becoming one of the important places in technology as well as in economy. Asian Countries have experienced remarkable economic growth in the last decade as represented by China. The Asian Polyolefin Workshop (APO) was planned to provide a venue for Asian scientists and engineers identifying and exploring the areas of common interests. The workshop was held in Nara on December 7th-9th, 2005, with more than 100 participants from China, Israel, India, Japan, Korea, Russia, Spain and Thailand. The following research topics were covered with 34 oral and 37 ...
Diplomatic List
Directory of foreign diplomatic officers in Washington.
Crosstalk: Skin Cells and Immune Cells in Inflammatory Skin Diseases
The skin is the human body's largest organ consisting of two layers: epidermis and dermis, and appendages: hair, and sweat glands. The skin not only wraps the body but also protects it from external stimuli and infection, perceives sensations such as pain and itch, and coordinates with various circulating immune cells for immune response/regulation. Recent studies have shown that inflammatory skin diseases, including psoriasis and atopic dermatitis, harbor systemic inflammation/immune abnormalities such as strong Th activation and expansion of specific immune cell subsets. Novel biologics and small molecule inhibitors targeting specific biomarkers and immune signals are much more effective and safer than conventional systemic therapies for these skin diseases.
Mechanism Design, Behavioral Science and Artificial Intelligence in International Relations
Recent advances in AI and Mechanism Design provide a vital tool for solving collective action problems, common in international relations. By using AI to optimize mechanisms for cooperation and coordination, we can better address issues such as climate change, trade, and security. Mechanism Design, Behavioral Science and Artificial Intelligence in International Relations shows readers how the intersection of Mechanism Design and Artificial Intelligence is revolutionizing the way we approach international relations. By using AI to optimize mechanisms, we can design better institutions, policies, and agreements that are more effective and efficient. Dr. Tshilidzi Marwala, United Nations Univer...
