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Membrane fusion is an important molecular event which plays a pivotal role in many dynamic cellular processes, such as exocytosis, endocytosis, membrane biogenesis, fertilization, etc. While many reports on the physico-chem1cal process involved in membrane fusion have appeared in the literature and much information has accumulated, there has been no comprehensiv~ meeting of workers in the field. A recent symposium which took place at the Center for Tomorrow, State University of New York at Buffalo, New York, April 27-29, 1987, was the first meeting of its kind to specifically address the molecular mechanisms of membrane fusion. The Symposium consisted of oral, workshop and poster presentatio...
This book is based on the invited and contributed papers presented at the 2nd International Conference on Anticarcinogenesis and Radiation Protection held at the National Bureau of Standards, Gaithersburg, Maryland, USA, on March 8-12, 1987. The conference documented developments that have taken place in areas that were addressed during the first conference in 1982. A number of new topics, such as biological response modifiers, were included because of their emerging relevance to anticarcinogenesis and radiation protection. The organization of the material in this book does not follow the conference program; rather, we have attempted to provide a different sequence for didactic reasons. The ...
The pteridines in their multitude of forms fulfill many roles in nature ranging from pigments to cofactors for numerous redox and one-carbon transfer reactions. This extraordinary diversity of function is unified by the unique chemistry of the pteridine heterocycle. The International Symposium on the Chemistry and Biology of Pteridines and Folates is a forum for presenting recent and exciting advances in this expanding field. In of ideas results that has often stimulated bringing together various disciplines, a synergy fresh approaches to major problems. The Tenth International Symposium held at Orange Beach, Alabama, March 21-23, 1993, proved no exception by providing new insights into fola...
Based on lectures given at the Ettore Majorana Centre's 25th Course on Resistance to Antitumor Agents in the Laboratory and Clinic: Problems and Implications, April 1988. A number of compounds have properties that inhibit the proliferation of neoplastic cells, and these compounds make up a large array of therapeutic agents now available to the physician treating cancer patients. Experimental evidence and controlled clinical trials have shown that the failure to reach the expected goal during treatment is principally due to the emergence of drug resistant cancer cell clones. The therapist's task is to design schedules using single or combined treatments in order to prevent or circumvent the obstacle of drug resistance. This book aims to update clinical oncologists dealing with this problem. Book club price, $51. Annotation copyrighted by Book News, Inc., Portland, OR
This book provides comprehensive coverage of gynaecological malignancies based on the 60th RCOG Study Group.
With expert guidance on all aspects of gynecologic surgery, Te Linde’s Operative Gynecology, Thirteenth Edition, edited by Drs. Linda Van Le and Victoria L. Handa, remains your go-to-resource from preoperative to postoperative care. Comprehensive, step-by-step instructions on how to perform all contemporary gynecologic procedures, updated diagnostic and management approaches, a greatly expanded illustration program, and new procedural videos, edited by Dr. Danielle Patterson, make this classic text an ideal reference for trainees as well as experienced practitioners.
Progress in Medicinal Chemistry
Advances in Carbohydrate Chemistry and Biochemistry
Doxorubicin: Anticancer Antibiotics details the development of doxorubicin as a wide-spectrum antitumor antibiotic. The book begins by tracing the discovery and development of doxorubicin, highlighting factors such as (a) the involvement of organic chemistry at an early stage, which allowed the rapid identification of doxorubicin and ensured its prompt availability for the clinical trials; (b) the well-established, pioneering expertise in experimental chemotherapy of Professor Aurelio di Marco and his group at Istituto Nazionale Tumori, Milan; and (c) the highly motivated interest of experienced clinicians. The remaining chapters provide an overview of basic studies in the area of medicinal chemistry and related fields that have resulted from doxorubicin development. Such studies have been concerned with both biochemical and biophysical investigations at the molecular level and at different levels of biological organization. A large body of work aimed at developing synthetic procedures for the drug and for new related analogs of potential clinical usefulness has also been carried out.
1978 Annual Plenary Meeting of the European Organization for Research on Treatment of Cancer, Paris, June 1978