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Extracellular Matrix-cell Interaction
The interaction of extracellular matrix (ECM) molecules with cells is important for cell differentiation and maintenance of tissue architecture, and elucidating these interactions will contribute to understanding the pathogenesis of many diseases involving ECM, such as rheumatoid arthritis, osteoarthrosis, or atherosclerosis. This book contains current information on the interaction between some representative extracellular molecules and cells. Chapters in the first half discuss the functional roles of such molecules or their receptors, including collagenase, fibrillins, laminin, aggrecan, tenascin-C, elastin, collagen, and PDGF receptors. The following chapters examine the regulation of expression of matrix-specific gene products and present disease-related analyses. Providing a basis for new therapeutic approaches to inflammatory or degenerative diseases of the connective tissue, the data compiled in this book will be valuable for a wide range of biomedical scientists.
Clinical Studies in Medical Biochemistry
This text uses a case-study approach to present the fundamentals of biochemistry and molecular biology in the context of human disease to students who will be involved in patient care. The 32 cases, carefully selected to cover common diseases and important principles, are supplemented by clinical descriptions of each disease and a comprehensive discussion of the underlying pathophysiological mechanisms and associated enzymatic and chemical alterations in tissues and body fluids. The Second Edition differs from its predecessor in several respects. It features seven new chapters on diseases not covered before. The Biochemical Perspectives section of each chapter has been expanded to include pe...
Extracellular Matrix and The Liver
Extracellular Matrix of the Liver addresses the basic science of the extracellular matrix and discussesnew strategies for the treatment of cirrhosis of the liver, with a primary focus on possible gene therapyapproaches. The chapters are divided into six sections as follows: Basic Science of Extracellular Matrix Cells Responsible for Extracellular Matrix Production Activation Mechanism of Hepatic Cells and Signal Transduction Basic Science for Extracellular Matrix Metabolism including Enzymes and their Inhibitors Matrix Mettaloproteinases and Tissue Inhibitors for Matrix Mettaloproteinases New Strategies for the treatment of Liver Cirrhosis Discusses the possibility of gene therapy for liver cirrhosis Includes information on new aspects of hepatic stellate cells Written by top experts in basic science and clinical hepatology
Guidebook to the Extracellular Matrix, Anchor, and Adhesion Proteins
Intended for postgraduate and professional researchers in biochemistry, biomedical sciences and cell biology, this text offers a guide to the extracellular matrix and adhesion proteins.
Fibrogenesis
Fibrogenesis: Cellular and Molecular Basis is the first volume to provide a synopsis of the rapid progress that has been documented in fibrogenesis over last couple of years, which significantly enhanced our understanding of the pathomechanisms of fibrotic diseases. Knowledge on molecular and celluar basis of fibrotic diseases has provided opportunities to develop selective and effective gene-based therapeutic options. The chapters in this book have been selected to provide comprehensive information on fibrogenesis, which is not limited to any specific organ. Individual chapters present mechanisms of fibrotic diseases involving lung, liver, kidney, heart, blood vessels, and more. The relevance and significance of inflammatory cytokines, chemokines, transcriptional factors, fibrogenic molecules, signaling cascade, and matrix remodeling in fibrogenesis are explained in depth, providing the reader with current and updated information.
The Chemistry and Biology of Mineralized Tissues
The proceedings of the Third International Conference (on title) held in Chatham, Mass., October, 1988. Presents coverage of many areas of the skeletal system, including new experimental techniques, research areas, ideas, and hypotheses. Discusses at length the chemical nature and structure of organic matrix components and their influence with respect to regulation of cell function. Annotation copyrighted by Book News, Inc., Portland, OR
