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Pathophysiology of Bone and Mineral Metabolism
Bone is the principal store for calcium and phosphate and one of the main regulators of mineral metabolism. The principal cells involved in bone remodeling are osteocytes, osteoblasts and osteoclasts, which maintain a precise equilibrium of bone mass. However, there are many factors that can affect bone and mineral homeostasis such as inadequate diet, microbiota alterations or aging. Furthermore, pathological conditions such as renal diseases, genetic disorders, obesity or inflammatory diseases can also potentially affect bone homeostasis, compromising bone health and leading to fractures and complications. Thus, integration of the mechanisms involved in mineral and bone alterations is key to understand bone physiology and its endocrine functions.
Statistical DNA Forensics
Statistical methodology plays a key role in ensuring that DNA evidence is collected, interpreted, analyzed and presented correctly. With the recent advances in computer technology, this methodology is more complex than ever before. There are a growing number of books in the area but none are devoted to the computational analysis of evidence. This book presents the methodology of statistical DNA forensics with an emphasis on the use of computational techniques to analyze and interpret forensic evidence.
Eileen Chang
Eileen Chang (1920–1995) is arguably the most perceptive writer in modern Chinese literature. She was one of the most popular writers in 1940s Shanghai, but her insistence on writing about individual human relationships and mundane matters rather than revolutionary and political movements meant that in mainland China, she was neglected until very recently. Outside the mainland, her life and writings never ceased to fascinate Chinese readers. There are hundreds of works about her in the Chinese language but very few in other languages. This is the first work in English to explore her earliest short stories as well as novels that were published posthumously. It discusses the translation of h...
Science Abstracts
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The Sinitic Civilization Book II
The Sinitic Civilization A Factual History through the Lens of Archaeology, Bronzeware, Astronomy, Divination, Calendar and the Annals The book covered the time span of history of the Sinitic civilization from antiquity, to the 3rd millennium B.C. to A.D. 85. A comprehensive review of history related to the Sinitic cosmological, astronomical, astrological, historical, divinatory, and geographical developments was given. All ancient Chinese calendars had been examined, with the ancient thearchs' dates examined from the perspective how they were forged or made up. The book provides the indisputable evidence regarding the fingerprint of the forger for the 3rd century A.D. book Shang-shu (remote...
Integrative Pharmacology-based Research on Traditional Medicine: Methodologies, Medical and Pharmacological Applications
ntegrative Pharmacology can be used to determine the multi-pharmacological effects of traditional medicines such as traditional Chinese medicine (TCM), Kampo, Sa-sang, Ayurveda, etc.). Through qualitative and quantitative pharmacokinetic-pharmacodynamic (PK-PD) correlations among multi-constituents and multi-targets, integrating chemical profiling, ADME/PK processes, molecular network calculation and resulting experimental validation, the use of Integrative Pharmacology has become widespread. The data has provided a novel paradigm to evaluate the druggability of bioactive ingredients of herbs or formulae, to decipher the pharmacological mechanisms of drug action and to screen potentially new indications for approved drugs and previously unidentified adverse events. On this basis, Integrative Pharmacology may offer an effective way to test the potential scientific basis for traditional medicines and to assess what roles of traditional medicine can and cannot play in pharmaceuticals.
Proceedings of COMPSTAT'2010
Proceedings of the 19th international symposium on computational statistics, held in Paris august 22-27, 2010.Together with 3 keynote talks, there were 14 invited sessions and more than 100 peer-reviewed contributed communications.
