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The Underlying Mechanisms and Novel Approaches for Diabetes and its Related Complications
Diabetes mellitus is a chronic metabolic disease characterized by elevated blood glucose levels, which severely affects the quality of life and survival of patients. The latest data from the International Diabetes Federation showed that there are approximately 537 million diabetic patients globally in 2021, and it is expected to reach 783 million by 2045. The treatment regime of diabetic patients mainly refers to the management of blood glucose and its complications. At present, typical hypoglycemic medications include insulin and non-insulin hypoglycemic drugs, which can be subdivided into a-glucosidase inhibitors, metformin, thiazolidinediones, sulfonylureas, glinides, DPP-4i, GLP-1RA, and...
Next Generation Sequencing Based Clinical Molecular Diagnosis of Human Genetic Disorders
Next Generation Sequencing technology has been applied to clinical diagnoses in the past three to five years using various approaches, including target gene panels and whole exomes. The purpose of this book is to summarize the experiences, the results, advantages and disadvantages, along with future development in the area of NGS-based molecular diagnosis. This up-to-date volume will not only provide the readers working with Next Generation Sequencing the basics on how to apply the technology to molecular diagnosis, but will present the results and experience of practical application.
Bilevel Optimization
2019 marked the 85th anniversary of Heinrich Freiherr von Stackelberg’s habilitation thesis “Marktform und Gleichgewicht,” which formed the roots of bilevel optimization. Research on the topic has grown tremendously since its introduction in the field of mathematical optimization. Besides the substantial advances that have been made from the perspective of game theory, many sub-fields of bilevel optimization have emerged concerning optimal control, multiobjective optimization, energy and electricity markets, management science, security and many more. Each chapter of this book covers a specific aspect of bilevel optimization that has grown significantly or holds great potential to grow...
China Environment and Development ReviewisChina's Environment and Development in the Era of Globalization
This book focuses on climate change and China, as well as international trade and China's environmental issues. It investigates the impact of globalization on sustainable development. As a new public issue, climate change has placed the whole world in two dilemmas, commercial rationality dominating our world cannot resolve such dilemmas, therefore greater wisdom is desperately needed, e.g. establishing new civilized norms and value system. The relationship between trade and poverty is discussed, and further effects of globalization on worldwide both environment and natural resource usage are analyzed by those quantitative analysis methods. The consequence of globalization is not only economi...
Deep Truth
The Crisis:Best-selling author and visionary scientist Gregg Braden suggests that the hottest topics that divide us as families, cultures, and nations-seemingly disparate issues such as war, terrorism, abortion, genocide, poverty, economic collapse, climate change, and nuclear threats-are actually related. They all stem from a worldview based upon the false assumptions of an incomplete science.The History:The obsolete beliefs of our modern worldview have brought us to the brink of disaster and the loss of all that we cherish as a civilization. Our reluctance to accept new discoveries about our relationship to the earth, one another, and our ancient past keeps us locked into the thinking that...
A Game, A Dream
meeting her at an incredible age his life had undergone an earth-shattering change ever since
Unwillingness
meeting her at an incredible age his life had undergone an earth-shattering change ever since
Reviews in Breast Cancer: 2023
Frontiers in Oncology is delighted to present the ‘Reviews in’ series of article collections. Reviews in Breast Cancer will publish high-quality review articles on key topics in the field. It aims to highlight recent advances in the field, whilst emphasizing important directions and new possibilities for future inquiries. The Reviews in Breast Cancer collection welcomes full-length, mini or systematic review papers. New articles will be added to this collection as they are published.
