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Co-signal Molecules in T Cell Activation
This book equips young immunologists and health professionals with a clear understanding of the fundamental concepts and roles of co-signal molecules and in addition presents the latest information on co-stimulation. The first part of the book is devoted to co-signal molecules and the regulation of T cells. Following an initial overview, subsequent chapters examine each co-signal molecule in turn and discuss the mechanisms by which co-signal molecules regulate the different types of T cell. The second part covers various clinical applications, including in autoimmune disease, neurological disorders, transplantation, graft-versus-host disease, and cancer immunotherapy. To date, co-stimulation blockade and co-inhibition blockade have shown beneficial effects and many additional clinical trials targeting co-signal molecules are ongoing. The mechanisms underlying these successful treatments are explained and the future therapeutic potential in the aforementioned diseases is evaluated. Co-signal Molecules in T Cell Activation will be a valuable reference guide to co-stimulation for basic and clinical researchers in the fields of both immunology and pharmaceutical science.
Process Intensification
Process Intensification is a comprehensive textbook and treats the theory of process intensification design, and all innovation steps from idea generation to commercial implementation, and all focused on contributing to the UN Sustainable Development Goals. This book covers the ‘hard’ elements of design, modelling, and experimental validations and the ‘soft’ elements, values of engineers, interests of stakeholders and beliefs of society.
