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The CCN family of genes currently comprises six secreted proteins (designated CCN16 i.e., Cyr61/CCN1; ctgf/CCN2; Nov/CCN3; WISP1/CCN4; WISP2/CCN5, and WISP3/CCN6) showing a strikingly conserved primary structure, with four modules sharing partial identity with IGF binding proteins, Von Willebrand protein, thrombospondin and several matricellular proteins and growth factors. The current view is that CCN proteins modulate signaling pathways that involve regulatory components of the extracellular matrix. As such, they likely act as a central hub in the regulation of mitosis, adhesion, apoptosis, extracellular matrix production, growth arrest and migration of multiple cell types. The 5th interna...
The basic objective of this report is to place the debate about the future of the Northern Sea Route into the larger picture of Arctic politics and the emerging agenda of the Arctic as a developing region in international society. National security and international environmental cooperation, are the objects of study employed, both separately and in various conceptual combinations, to realize this purpose. To help me in this, I was privileged to draw on the profound expertise of my highly esteemed co-authors, Professor Franklyn Griffiths at the University of Toronto and Senior Researchers at IMEMO in Moscow: Raphael Vartanov, Alexei Roginko and Alexander Kolossov. To their cooperative spirit...
An up to date overview of the knowledge and methods used to control living organism responses to implantable devices.
Includes entries for maps and atlases.
The ultimate comprehensive introduction to GIS-now in an updated, expanded new edition. "This book is well designed, solidly constructed, and finely crafted; those who depend on it as they set out to explore our spatial world will be well served. . . . If we are to solve many of the problems facing us-in the cities, in the wild areas of the earth, in the atmosphere and the oceans, problems of the earth as a whole-we shall need the help of skilled users of GIS technology. If readers can master what is in this volume, they will be well started on this enterprise." -From the Foreword by Jack Dangermond,President of ESRI. From reviews of the previous edition: * "Comprehensive and easy to read. ....
This book represents an alternative perspective on international elite sport systems. It focusses on the embedded multi-level nature of leadership, and the scope that this might give for degrees of leadership autonomy and discretion. The chapters show how mechanisms of leadership on different levels interact. The nature and mix of leadership mechanisms reflect values and expectations related to specific political, normative and commercial sport contexts. Three introductory chapters outline key elements of these dimensions of elite sport contexts. Seven empirical cases illustrate how national contexts facilitate and constrain leadership practices, related to specific sports across Russia, Chi...