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Sleep Spindles: Breaking the Methodological Wall
In the last decade, sleep spindles have attracted steadily increasing attention. This interest is motivated by the many intriguing relationships between spindles and various diseases (e.g., schizophrenia, Parkinson, Alzheimer, autism, mental retardation), recovery processes (e.g., post brain stroke), and cognitive faculties (e.g., memory consolidation, intelligence, dream recall, sleep preservation). Nonetheless, a methodological wall has impeded the study of sleep spindles. Their investigation rests heavily on our ability to reliably and consistently identify spindle patterns from background EEG activity, a task involving many obstacles, including: a fuzzy definition of spindles, low inter-...
The Age of Genomes
A leading geneticist explores what promises to be one of the most transformative advances in health and medicine in history Almost every week, another exciting headline appears about new advances in the field of genetics. Genetic testing is experiencing the kind of exponential growth once seen with the birth of the Internet, while the plummeting cost of DNA sequencing makes it increasingly accessible for individuals and families. Steven Lipkin and Jon Luoma posit that today’s genomics is like the last century’s nuclear physics: a powerful tool for good if used correctly, but potentially dangerous nonetheless. DNA testing is likely the most exciting advance in a long time for treating ser...
Mathematical Reviews
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The Mathematics of Finite Elements and Applications X (MAFELAP 1999)
The tenth conference on The Mathematics of Finite Elements and Applications, MAFELAP 1999, was held at Brunel University during the period 22-25 June, 1999. This book seeks to highlight certain aspects of the state-of-the-art theory and applications of finite element methods of that time. This latest conference, in the MAFELAP series, followed the well established MAFELAP pattern of bringing together mathematicians, engineers and others interested in the field to discuss finite element techniques. In the MAFELAP context finite elements have always been interpreted in a broad and inclusive manner, including techniques such as finite difference, finite volume and boundary element methods as well as actual finite element methods. Twenty-six papers were carefully selected for this book out of the 180 presentations made at the conference, and all of these reflect this style and approach to finite elements. The increasing importance of modelling, in addition to numerical discretization, error estimation and adaptivity was also studied in MAFELAP 1999.
Faut-il faire vacciner son enfant ?
Faut-il faire vacciner son enfant ? Une question que certains ne se posent plus, tant la pratique est entrée dans les moeurs ; jusqu’aux pédiatres qui ne prennent parfois pas la peine de nous informer sur les risques, pourtant bien présents. Pourquoi certaines injections obligatoires sont-elles systéma-tiquement combinées avec des vaccins facultatifs ? Ces produits sont-ils sûrs ? Comment et pourquoi les autorités compétentes minimisent, voire ne reconnaissent pas les effets indésirables graves des vaccins ? Quels mécanismes derrière le dogme vaccinal ? Au travers des témoignages recueillis et de l’avis de professionnels de la santé, Virginie Belle lève le voile sur le syst...
Managing Football
* Contributed to by a world-class team of experts and well edited by two specialists in football management * Comprehensive coverage of all key issues in football internationally, with a strong balance of academic and practitioner analysis and comment * Presented in a clear and structured format, easy-to-use for readers with clear signposts throughout the text and online resources for lecturers
Insights into Receptor Function and New Drug Development Targets
This book describes the current state of knowledge in receptor function in the development of new drugs. Science is on the verge of viewing effector molecules and other regulatory sites as therapeutic targets for the amelioration of human and animal disease. The book reviews the availability of state-of-the-art tools that allow measurement of interactions and afford unprecedented insight into the biomolecular interactions that present novel approaches to drug design.
Index Medicus
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Huntington’s Disease
Huntington's disease (HD) is one of the most common dominantly inherited neurodegenerative disorders, characterized by a clinical trial of movement disorder, cognitive deficits, and psychiatric symptoms. Huntington’s Disease: Pathogenic Mechanisms and Implications for Therapeutics, reviews the most up-do-date content on HD pathogenic mechanisms and cutting-edge testing of therapeutic strategies for HD. Chapters explore areas such as, normal huntingtin biology in brain development and function, genetic modifiers of HD in patients, molecular pathogenic mechanism in HD, and mechanisms underlying selective neuronal vulnerability Reviews the clinical course and genetics of HD Reviews the biolog...
