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Calcium Antagonists
Although the importance of calcium (Ca2+) in the maintenance of cardiac contractility was recognized as early as 1880, the critical role of the ion in the contractile process in skeletal, cardiac, and smooth muscle has only been established within the last three decades. As the complexity of the pharmacological actions of the Ca2+ channel inhibitors grows, there is a continued need to further clarify the inhibitors, both chemically and functionally. This volume provides an update of the field based on the work presented at the 5th International Symposium on Calcium Antagonists: Pharmacology and Clinical Research. It reviews the current state of the growing area of molecular biology of Ca2+ channels. In the cardiovascular area, in addition to the well-established clinical uses of Ca2+ channel inhibitors, exciting new work pointing to an application in atherosclerosis is described. The book also includes important uses of Ca2+ antagonists in novel areas of interest such as the gastrointestinal tract, renal protection and multi-drug resistance.
Myocardial Protection by Calcium Antagonists
About the Book There are vast amounts of new data emerging in the study of calcium antagonist drugs. The major issues involved are no longer just the effects of calcium antagonist drugs in angina or hypertension but their possible postinfarct protective effects, both to provide prophylaxis and to improve left ventricular function. New trials have also changed our thinking. One major trial suggested that the use of one of these agents in postinfarct patients with no history of heart failure in the acute infarct stage was not only safe but could confer positive protection from reinfarction and possibly from sudden death. Another study, also in postinfarct patients but with a different agent, h...
Physiology and Pathophysiology of the Heart
The first edition of this book was quite successful. As in the first edition, the book is divided into two major sections: cardiac muscle and coronary circula Several complimentary book reviews appeared soon tion. The book is multidisciplinary and includes after the first edition was published, and written and membrane biophysics, electrophysiology, physiol oral words of praise and appreciation were given both ogy, pathophysiology, pharmacology, biochemistry, to the publisher and to me by quite a few individuals. and ultrastructure. Thus, the book attempts ro It is because of such positive comments and reactions that the publisher and I decided to embark on a integrate all relevant aspects o...
2nd International Adalat® Symposium
The First Adalat Symposium held in Tokyo in 1973, presented important experimental and clinical results which had been collected in Europe and Japan with the new coronary therapeutic agent. The European scientists had an opportunity to discuss the problems and results personally with their Japanese colleagues. The Second Adalat Symposium was held in Amsterdam within a year with the purpose of bringing together mainly scientists within Europe. The results discussed in Tokyo have been extended and supplemented through additional experiences. Contributions in basic science are presented, but most important are those clinical studies, which support and extend proof of the drug's efficacy in huma...
Treatment with Gallopamil
Calcium antagonists are currently the most extensively investigated drugs for the treatment of heart disease. They are used worldwide with great success and a comparatively low incidence of adverse reactions. The most prevalent and threatening diseases in modem industrialized societies - the various forms and complications of coronary arteriosclerosis and arterial hypertension - are amenable to treatment with calcium antagonists. The pharmacological spectrum of calcium antagonists is highly specific and was supplemen ted a few years ago by gallopamil, a verapamil analogue. The experimental work reported at this symposium was concerned with effects of gallopamil on the electrophysiology of th...
Vascular Smooth Muscle / Der Gefäßmuskel
This book summarizes the papers presented at the International Symposium on vascular smooth muscle, organized in combination with the XXV Interna tional Congress of Physiological Sciences by the German Society of Angiology e. V. Honorary Presidents were Professor Dr. Dr. h. c. K. Wezler and Profes sor Dr. Dr. h. c. H. E. Bock. The annual meeting of the SOCiety of Angiology was combined with the Symposium. It was held at the Physiological Institute of the University of TUBINGEN, an appropriate setting, since in the last century numerous scientists from this institute were engaged in special problems con nected with the vascular system and muscles. The topics of this meeting covered a wide fie...
Adalat
As little as 30 years ago, cardiovascular research at Bayer was just a small sideline with in an environment dominated by chemotherapy research, and only 15 years ago, Bayer's pharmaceutical business was confined to European and Latin Ameri can countries, with sales in cardiovascular pharmaceuticals close to zero. It goes without saying that Adalat has changed the company as a whole in its research, development, and marketing, both in Germany and, most importantly, world wide. In research and development, Adalat has led the way in to new areas such as hypertension, acute neurology, dementia, atherosclerosis, and heart failure. In pharmacology, Adalat was present at the dawning of the second ...
