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Glucose Lowering by SGLT2-inhibitor Empagliflozin Accelerates Atherosclerosis Regression in Hyperglycemic STZ-diabetic Mice
Abstract: Diabetes worsens atherosclerosis progression and leads to a defect in repair of arteries after cholesterol reduction, a process termed regression. Empagliflozin reduces blood glucose levels via inhibition of the sodium glucose cotransporter 2 (SGLT-2) in the kidney and has been shown to lead to a marked reduction in cardiovascular events in humans. To determine whether glucose lowering by empagliflozin accelerates atherosclerosis regression in a mouse model, male C57BL/6J mice were treated intraperitoneally with LDLR- and SRB1- antisense oligonucleotides and fed a high cholesterol diet for 16 weeks to induce severe hypercholesterolemia and atherosclerosis progression. At week 14 al...
Scientific Report
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AHA Scientific Sessions 2016: Program Information
The American Heart Association’s Scientific Sessions 2016 is bringing big science, big technology, and big networking opportunities to New Orleans, Louisiana this November. This event features five days of the best in science and cardiovascular clinical practice covering all aspects of basic, clinical, population and translational content.
The London Gazette
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What Makes a Garden
'One of the year’s most engrossing, thought-provoking books’ The English Garden A reflective second book by Jinny Blom (author of The Thoughtful Garden), one of the world’s leading garden designers. What Makes a Garden builds upon the work of The Thoughtful Garden, giving a broader idea of how she thinks about garden design. In particular it emphasizes her multi-disciplinary approach, which embraces architecture, conservation and art, coupled with a strong holistic thread. This fascinating and insightful book looks at how a garden should please all five senses; how it is an alchemical mix of the inanimate and the living; and also how it has to accommodate both the effects of time and t...
Adam Kimmel
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