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Chromosomal Alterations
Due to sensitive molecular biological techniques, our understanding of chromosomal aberrations is steadily increasing. Provided here is a review of basic and applied aspects of the field. Chromosome structure, induction of DNA lesions by different clastogenic agents and their repair, induction of aberrations by agents which affect specific sequences in the DNA, and factors affecting induction and yield of chromosomal aberrations are covered. Further, topics such as automation of aberration scoring, problems associated with using chromosomal aberrations and micronuclei in population monitoring and the importance of chromosomal aberration assays in mutagenicity testing of chemicals are included.
Some Aspects of Chromosome Structure and Function
It was at the end of the 19th century that a Swiss biologist, Karl Nageli first proposed the existence of hereditary organelles that carried information from parent to offspring. Ensuing decades experienced vigorous studies that led to the development of discovery that chromosomes are indeed the carriers of genetic information. Subsequent studies, especially by Morgan and Bridges, established unequivocally the chromosome theory of inheritance. Today, the structure of chromosome is well established. At the physical level, eukaryotic chromosomes are composed of a single, linear, double helix of DNA. The elementary helical structure involves nucleosomes, comprised of histones around which the DNA is wrapped. A hierarchy of higher order of chromosomal architecture may possibly be responsible for the regulation of gene helical structures expression. The localized condensations of DNA constitute chromomeres. Uncoiled structures sometimes extending from chromomeres, which form loops, is the result of discontinuities in the regular coiling of the DNA in the chromosome.
DNA Repair and Human Disease
DNA Repair and Human Disease highlights the molecular complexities of a few well-known human hereditary disorders that arise due to perturbations in the fidelity of diverse DNA repair machineries.
The Minimum Method
When it comes to looking and feeling your best, less really can be more. Discover how to maximize your sleeping, eating, exercising—even thinking and breathing—with minimum effort. The truth is most people don’t actually need grueling, extreme workouts or aggressively limited diets to lose weight and feel proud to flaunt their bodies in bathing suits. What they need is a plan that is focused on efficiency—the best results for the least amount of time and effort—and one that is actually designed to be maintained for more than 30 days. In The Minimum Method, by nutrition expert and celebrity fitness trainer Joey Thurman, you’ll learn a wealth of practical advice, simple nutrition t...
A Parent’s Guide to Childhood Cancer
"Indispensable . . . Dr. Beine provides a practical primer on integrative cancer therapies for children based on a metabolic framework of understanding the disease. I can’t recommend [this book] enough.”—Chris Kresser, MS, LAc, founder of Kresser Institute; New York Times bestselling author An invaluable, revolutionary, research-based resource for parents—grounded in nutrition, detoxification, and mental wellbeing, while aiming to reduce suffering and promote long-term recovery. “Your child has cancer.” Every day, forty-three American families hear these words, thrusting them headlong into the terrifying and unfamiliar territory of pediatric oncology. In A Parent’s Guide to Chi...
Nature
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