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Methods in Bone Biology
Methods in Bone Biology is unique in being devoted to describing the methodology used by bone researchers. This book describes in detail the techniques of cell and organ culture used in the study of bone and bone cell function and the techniques used to monitor the skeleton and skeletal remodelling both in clinical and experimental settings.
Genomics and Models of Nerve Sheath Tumors
Nerve sheath tumors can be a significant cause of morbidity for many patients. These include benign tumors such as schwannomas, diffuse and plexiform neurofibromas, and atypical neurofibromas, as well as the aggressive soft tissue sarcoma known as the malignant peripheral nerve sheath tumor (MPNST). Nerve sheath tumors occur sporadically and in the context of the clinical neuro-genetic tumor predisposition syndromes neurofibromatosis type 1 (NF1) and type 2 (NF2). Historically, the mainstay of treatment for nerve sheath tumors has been surgery. However, for both benign and malignant nerve sheath tumors, there is a high recurrence rate, highlighting the pressing need for novel therapies. As w...
Kelley's Textbook of Rheumatology
Helps you to better understand scientific underpinnings of rheumatic diseases, so that you can better manage your patients.
Bone Tumor Pathology, An Issue of Surgical Pathology Clinics
Bone Tumor Pathology, An Issue of Surgical Pathology Clinics
Neurofibromatosis Type 1
Neurofibromatosis type 1 (NF1), caused by mutational inactivation of the NF1 tumour suppressor gene, is one of the most common dominantly inherited human disorders, affecting 1 in 3000 individuals worldwide. This book presents in concise fashion, but as comprehensively as possible, our current state of knowledge on the molecular genetics, molecular biology and cellular biology of this tumour predisposition syndrome. Written by internationally recognized experts in the field, the 44 chapters that constitute this edited volume provide the reader with a broad overview of the clinical features of the disease, the structure and expression of the NF1 gene, its germ line and somatic mutational spectra and genotype-phenotype relationships, the structure and function of its protein product (neurofibromin), NF1 modifying loci, the molecular pathology of NF1-associated tumours, animal models of the disease, psycho-social aspects and future prospects for therapeutic treatment.
Recent Advances in Histopathology: 24
Recent Advances in Histopathology: 24 features a collection of in depth reviews of the latest developments in the field. Written in an accessible and easy to read format and featuring such topics as the implementation of digital histology, molecular pathology of pancreatic cancer and the big bang theory of tumour development: how cancers start, each chapter provides a comprehensive overview, and emphasises the salient points of interest. This latest volume in the series is an invaluable resource for busy clinicians and those sitting FRCPath examinations. Key Points 12 chapters summarising important recent advances within the field of Histopathology All topics are written in a practical and clinically relevant manner, further enhanced by the ‘key clinical points for practice’ sections at the end of each chapter Provides an effective exam revision tool for FRCPath(UK) All chapters written by expert authors ensuring authoritative and accurate content Full colour photographs throughout
Bone Cancer
The epidemiological and clinical importance of bone metastasis has long been recognized, but the past decade has seen an explosion in the fields of bone biology and bone cancer research. This period of time has been marked by a number of key discoveries that have led to the opening up of entirely new areas for investigation as well as new therapies which combine surgery and biological therapeutic approaches.Bone is a common site of cancer metastases - cancer cells commonly develop in bone and spread to other organ systems through the bloodstream. For example, the incidence of bone metastases in breast and prostate cancers is 70%, whereas it is only 30 to 40% in metastatic lung cancer. In cli...
