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AACR 2017 Proceedings: Abstracts 1-3062
The AACR Annual Meeting highlights the best cancer science and medicine from institutions all over the world. Attendees are invited to stretch their boundaries, form collaborations, attend sessions outside their own areas of expertise, and learn how to apply exciting new concepts, tools, and techniques to their own research. Part A contains abstracts 1-3062 accepted for the 2017 meeting.
Cancer Research
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Neurobiology of Huntington's Disease
In 1993, the genetic mutation responsible for Huntington's disease (HD) was identified. Considered a milestone in human genomics, this discovery has led to nearly two decades of remarkable progress that has greatly increased our knowledge of HD, and documented an unexpectedly large and diverse range of biochemical and genetic perturbations that see
Protein Engineering
A one-stop reference that reviews protein design strategies to applications in industrial and medical biotechnology Protein Engineering: Tools and Applications is a comprehensive resource that offers a systematic and comprehensive review of the most recent advances in the field, and contains detailed information on the methodologies and strategies behind these approaches. The authors—noted experts on the topic—explore the distinctive advantages and disadvantages of the presented methodologies and strategies in a targeted and focused manner that allows for the adaptation and implementation of the strategies for new applications. The book contains information on the directed evolution, rat...
Rare Earth Nanotechnology
This book provides in-depth aspects of nanotechnology of rare earth (RE) materials. It starts with a review on the physical and chemical properties of RE elements, followed by a discussion on various strategies in fabricating nanosized RE materials. It describes various techniques in derivatizing surface molecules onto nanosized RE materials. A con
Northern Girls: Life Goes On
Qian Xiaohong is born into a sleepy Hunan village, where the new China rush towards development is a mere distant rumour. A buxom, naïve sixteen-year-old, she yearns to leave behind hometown scandal, and joins the mass migration to the bustling boomtown of Shenzhen. There, she must navigate dangerous encounters with ruthless bosses, jealous wives, sympathetic hookers and corrupt policemen as she tries to find her place in the ever-evolving society. Hardship and tragedy are in no short supply as her journey takes her through a grinding succession of dead end jobs. To help her through this confusing maze, Xiaohong finds solace in the close ties she makes with the other migrant girls – the community of her fellow 'northern girls' – who quickly learn to rely on each other for humour and the enjoyment of life's simple pleasures. A beautiful coming-of-age novel, Northern Girls explores the inner lives of a generation of young, rural Chinese women who embark on life-changing journeys in search of something better.
Water-Insoluble Drug Formulation
Properties and Formulation: From Theory to Real-World Application Scientists have attributed more than 40 percent of the failures in new drug development to poor biopharmaceutical properties, particularly water insolubility. Issues surrounding water insolubility can postpone or completely derail important new drug development. Even the much-needed reformulation of currently marketed products can be significantly affected by these challenges. More recently it was reported that the percentage increased to 90% for the candidates of new chemical entities in the discovery stage and 75% for compounds under development. In the most comprehensive resource on the topic, this third edition of Water-In...
