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Phytochemicals Targeting Tumor Microenvironment in Gastrointestinal Cancers
Gastrointestinal (GI) malignancies account for a large portion of cancers worldwide. Although incidence of esophageal, gastric, and colorectal cancers has decreased in recent years, pancreatic and liver cancer have increased. The mainstay of GI cancer therapy is chemoradiation and surgery. Despite significant medical advancements, diagnosis and therapy for GI cancers remain challenging due to tumor cell resistance to chemoradiotherapy. The tumor’s increased cell signalling due to excessive transcription factor activation and increased stellate cell activity leads to collagen deposition formation of a dense stroma around the tumor, which prevents drugs from reaching the malignant cells. This leads to tumor chemoresistance. To circumvent these difficulties, drug therapy targeting the tumor’s specific microenvironment and the additive anticancer effect of phytochemicals can allow for more effective treatment. This volume will be the first on the market on the topic of phytochemicals and their effect on the tumor microenvironment (TME). TME is an emerging area of research and the book will be a welcome introductory addition to the field.
The Trust Transformation
The Trust Transformation unveils a revolutionary approach to fostering deeper connections and achieving success in one’s personal and professional life. The Trust Transformation emerged as an evidence-based training program at AdventHealth during the COVID-19 pandemic, teaching the power and principles of interpersonal trust. Initially offered as a four-hour class for employees and delivered as a workshop for leadership teams in the organization, thousands of team members have since completed the course. Since its launch, the program has been tested in numerous business and organizational cultures. Now, creators Roy Reid and Dr. Omayra Mansfield offer these principles to all who want to un...
Revisional Surgery, An Issue of Clinics in Podiatric Medicine and Surgery
Guest edited by Dr. Sean Grambart, this issue of Clinics in Podiatric Medicine and Surgery will cover several key areas of interest related to Revisional Surgery. This issue is one of four selected each year by our series Consulting Editor, Dr. Thomas Chang. Articles in this issue include but are not limited to: Revision of Failed First MTPJ Implant; Failed Hammertoe Revision; Revision for Failed Brostrum; Revision Surgery for Failed TAR; Revision of Malalinged Nonunion Lapidus; Revision of Recurrent Neuroma; Revision Surgery Failed OLT; Revision Surgery for the Achilles Tendon; Revision Surgery for Peroneal Tendon Tears; Revision of the Malreduced Syndesmosis; and Biologics for Tendon Surgery, among others.
Principles and Practice of Robotic Surgery - E-Book
Robot-assisted surgery, soon to be incorporated into most surgical disciplines, can reduce postoperative complications by up to 50%, and has been shown to result in reduced blood loss, earlier hospital discharge, and faster return to normal activity for the patient. Edited by master surgeon Tony Costello, and with contributions from the world's best and most experienced robotic surgeons worldwide, Principles and Practice of Robotic Surgery is an up-to-date, all-in-one reference that provides step-by-step instruction for practicing surgeons and those who are entering robotic surgery training. This first-of-its-kind text discusses new technologies and their application in each surgical subspec...
Rail-Trails Southeast
Explore 79 of the best rail-trails and other multiuse pathways in Alabama, Georgia, North Carolina, and South Carolina. All across the country, unused railroad corridors have been converted into public multiuse trails. Level and accessible, these paths are ideal for a brisk fitness walk, bike ride, or stroll with the family. In Rail-Trails Southeast, the experts from Rails to Trails Conservancy present the best of these routes, as well as other multiuse pathways, in Alabama, Georgia, North Carolina, and South Carolina. Many rail-trails are paved and run within view of the most scenic parts of town. Others offer rugged scenery on ungroomed, mostly dirt, and somewhat wild paths. Explore the Hu...
We're Here to Help
"Guardianship, sometimes called conservatorship, is an ever-growing phenomenon. Some of these arrangements are truly beneficial, but countless others are unwanted, unnecessary, and violate constitutionally protected human rights. Award winning journalist, Diane Dimond, dissects the mysterious, ever-expanding, and complicit cottage industry of individuals who profit off the confinement of others"--
Robot-Assisted Radical Prostatectomy
This book comprehensively covers the techniques available for robot- assisted prostatectomy. Chapters feature detailed descriptions of how to successfully perform a variety of relevant techniques including the reconstruction of continence mechanisms and the use of the transperitoneal RALP anterior approach. Potential complications, preoperative and postoperative management strategies are also discussed, enabling the reader to develop a thorough understanding of how to apply a range of relevant methodologies into their day-to-day clinical practice and avoid commonly encountered pitfalls. Robot-Assisted Radical Prostatectomy: Advanced Surgical Techniques provides a practically applicable resource for all practicing and trainee urologists seeking a detailed overview of the latest advances in robot-assisted surgical procedures and current management strategies applicable to prostatectomy.
Transforming the Heart of Practice
This unique, step-by-step guide offers a comprehensive exploration of burnout and physician wellbeing, a vital issue that steadily has become widely discussed in the professional and mainstream press. More than twenty chapter authors contribute to this multidimensional volume, including physicians, psychologists, researchers, healthcare administrators, chaplains, professional coaches, and counselors. Section one of the book establishes context, provides a brief overview of the phenomenon of physician burnout, establishes its validity, and makes a case for the reason it has emerged as a critical issue in American healthcare. Section two provides a rationale for healthcare institutions (hos...
Handbook of Robotic Surgery
Handbook of Robotic Surgery serves as a primer covering the main areas of knowledge in robotic surgery. This comprehensive book provides essential information on all aspects related to robotic surgery, from the present up to the future. The discussion presented in sections ranges from the historical background of robotic surgery up to more recent and future technological innovations such as remote controls, surgically distant collaboration, simulators, modern surgical robotics, fluorescence-guided surgery, and virtual reality. The book also contains sections dedicated to the safety conditions in surgery and patient protection, which will be suitable for surgeons, health professionals, biomed...
Pleura
This book provides the thoracic community and pleura experts with an up-to-date surgical vision of pleura pathology. It provides in-depth knowledge and a better understanding of the indications, positioning techniques, and management of chest drains and indwelling catheters, which are commonly utilized in the management of the pleural disease. The book addresses complex topics such as bronchopleural fistula and postoperative empyema as well as pneumothorax.
