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Oncolytic Virotherapy
Using viruses to treat cancer is an established concept, and many viruses have shown promising anti-tumor efficacies. Oncolytic viruses are safe and well-characterized pathogens with a stable genome. The outstanding clinical results for oncolytic virotherapy deserve serious attention and consideration to make it a treatment option alongside classical cancer therapeutics. Virotherapy uses replication-competent oncolytic viruses to replicate and destroy cancer cells selectively. The transformed nature of cancer cells offers a permissive environment for some viruses’ replication and to complement viral mutations. The in situ amplification and spread within the tumor mass is the key benefit of such replication-competent viruses. Oncolytic virotherapy is divided into two main groups, according to tumor specificity: naturally oncolytic viruses to replicate in human cancer cells; and gene-modified viruses engineered to accomplish selective oncolysis.
E. Coli Infections
Gram-negative Escherichia coli (E. coli) bacteria are the most numerous commensal aerobic germs located in the human colon. Diarrhea caused by E. coli pathogenic strains is a major cause of death in developing countries, especially the sub-Saharan and South Asian areas. Some strains cause diarrhea, and all of them may produce an infectious disease. This book includes ten chapters covering the main aspects of infections related to E. coli, their pathogenic mechanisms, treatments, and resistance to diverse antibiotics.
Intelligent Circuits and Systems for SDG 3 – Good Health and well-being
ICICS is a series of conferences initiated by School of Electronics and Electrical Engineering at Lovely Professional University. Looking at the response to the conference, the bi-annual conference now onwards will be annual. The 5th International Conference on Intelligent Circuits and Systems (ICICS 2023) will be focusing on intelligent circuits and systems for achieving the targets in Sustainable Development Goal (SDG) 3, identified as ‘Good Health and Wellbeing’ by United Nations (Refs: https://sdgs.un.org/goals/goal3, https://sdg-tracker.org/).
ICU Care of Abdominal Organ Transplant Patients
Pre- and post-operative care of transplant patients is an aspect of Critical Care Medicine in which most ICU physicians and nurses have received little or no formal training and are left to cope with this complex population with only spotty, incomplete 'on-the-job experience' as a guide. In response to this clinical knowledge gap, this book provides a concise 'at the bedside' resource for clinicians caring for abdominal organ transplant patients before and after surgery.
Processing of Heavy Crude Oils
Unconventional heavy crude oils are replacing the conventional light crude oils slowly but steadily as a major energy source. Heavy crude oils are cheaper and present an opportunity to the refiners to process them with higher profit margins. However, the unfavourable characteristics of heavy crude oils such as high viscosity, low API gravity, low H/C ratio, chemical complexity with high asphaltenes content, high acidity, high sulfur and increased level of metal and heteroatom impurities impede extraction, pumping, transportation and processing. Very poor mobility of the heavy oils, due to very high viscosities, significantly affects production and transportation. Techniques for viscosity red...
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Serious Games Development and Applications
This book constitutes the refereed proceedings of the 5th International Conference on Serious Games Development and Applications, SGDA 2014, held in Berlin, Germany, in October 2014. The 14 revised full papers presented together with 4 short papers were carefully reviewed and selected from 31 submissions. The focus of the papers was on the following: games for health, games for medical training, serious games for children, music and sound effects, games for other purposes, and game design and theories.
