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Late-Stage Fluorination of Bioactive Molecules and Biologically-Relevant Substrates
Late-Stage Fluorination of Bioactive Molecules and Biologically-Relevant Substrates reviews how the use of these techniques on compounds with already known and relevant biological activity can provide new pharmaceutical leads with improved medicinal properties. The fluorination strategies discussed take into account both conventional and novel reagents, including nucleophilic, electrophilic, those of a radical nature, and diverse families of organic compounds, such as (hetero) aromatic rings and aliphatic substrates. Drawing on the authors' expert knowledge, this book provides researchers with a broad set of applicable methods to use in their work. Highlights the latest developments in the field in a concise volume Provides details of key fluorinating reagents across diverse families of organic compounds Explores the current applications and future potential of fluorine in drug development
Illicit Drugs in the Environment
Illicit drugs are an emerging class of environmental contaminants and mass spectrometry is the technique of choice for their analysis. This landmark reference discusses the analytical techniques used to detect illicit drugs in wastewater and surface water, details how to estimate the levels of contaminants in the environment, and explores the behavior, fate, and toxic effects of this new class of contaminants, now a ubiquitous presence in wastewater and surface water. The book details how an estimate of illicit drug consumption in a given population can be developed from an analysis of the residues of illicit drugs in wastewater. An important resource for analytical chemists, environmental researchers, forensic scientists, biologists, and toxicologists.
Xenobiotics in the Urban Water Cycle
The history of chemistry and pharmaceutical sciences is an impressive success story. The products of chemical and pharmaceutical industries are present eve- where in our everyday life. They help to pursue the modern way of living and they contribute to our high standard of living and safety, mobility, communication te- nologies, food, health, textiles and drinking water treatment, among many others. These products are labeled under the categories: pharmaceuticals, pesticides, det- gents, fertilizers, dyes, paints, preservatives, food additives and personal care pr- ucts, to name a few. Within these categories, groups of chemicals with similar structures can be found. However, often groups of...
Hematology
Hematology encompasses the physiology and pathology of blood and of the blood-forming organs. In common with other areas of medicine, the pace of change in hematology has been breathtaking over recent years. There are now many treatment options available to the modern hematologist and, happily, a greatly improved outlook for the vast majority of patients with blood disorders and malignancies. Improvements in the clinic reflect, and in many respects are driven by, advances in our scientific understanding of hematological processes under both normal and disease conditions. Hematology - Science and Practice consists of a selection of essays which aim to inform both specialist and non-specialist readers about some of the latest advances in hematology, in both laboratory and clinic.
Climate Change 2022 – Impacts, Adaptation and Vulnerability
The Working Group II contribution to the Sixth Assessment Report of the Intergovernmental Panel on Climate Change (IPCC) provides a comprehensive assessment of the scientific literature relevant to climate change impacts, adaptation and vulnerability. The report recognizes the interactions of climate, ecosystems and biodiversity, and human societies, and integrates across the natural, ecological, social and economic sciences. It emphasizes how efforts in adaptation and in reducing greenhouse gas emissions can come together in a process called climate resilient development, which enables a liveable future for biodiversity and humankind. The IPCC is the leading body for assessing climate change science. IPCC reports are produced in comprehensive, objective and transparent ways, ensuring they reflect the full range of views in the scientific literature. Novel elements include focused topical assessments, and an atlas presenting observed climate change impacts and future risks from global to regional scales. Available as Open Access on Cambridge Core.
Streamlining Free Radical Green Chemistry
This practical, concise guide showcases the sustainable methods offered by green free radical chemistry and summarizes the fundamental science involved.
The Cellular Basis of Central Nervous System HIV-1 Infection and the AIDS Dementia Complex
In this exciting symposium, the editor brings to print important new information on AIDS and how HIV affects the brain. Each chapter focuses on one or more of the cell types that reside in or traffic through the central nervous system (CNS). Each of these cells is important to considerations of the pathogenesis of the CNS. Neurologists, AIDS physicians, and other professionals caring for AIDS patients will find that this “cell-based” view provides a unique perspective and that it will guide and stimulate future investigation of this clinically important and pathogenetically intriguing disorder. The editor also introduces some general considerations for therapeutic intervention of AIDS de...
Climate and Culture
Discusses how culture both facilitates and inhibits our ability to address, live with, and make sense of climate change.
Socio-Environmental Research in Latin America
This contributed volume presents relevant examples of socio-environmental research that highlight the challenges and opportunities of using geotechnologies in interdisciplinary settings across the vast, culturally, and environmentally mega-diverse region known as Latin America. While remote sensing has been mostly used for mapping and monitoring physical features, geographic information systems open up opportunities for the integration of socio-economic and environmental data collected through individual and community-based surveys, in-situ measurements, and other participatory research techniques to offer additional analytically grounded power when evaluating socio-environmental processes t...
