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Metabolic Adaptation to Cell Growth and Proliferation in Normal and Pathological Conditions
Proliferating cells must adapt their metabolism to fulfill the increased requirements for energy demands and biosynthetic intermediates. This adaptation is particularly relevant in cancer, where sustained rapid proliferation combined with the harsh conditions of the tumor microenvironment represent a major metabolic challenge. Noteworthy, metabolic reprogramming is now considered one of the hallmarks of cancer. However, the one size fits all rarely applies to the metabolic rewiring occurring in cancer cells, which ultimately depends on the combination of several factors such as the tumor’s origin, the specific genetic alterations and the surrounding microenvironment. In the present Research Topic, we compile a series of articles that discuss different metabolic adaptations that proliferating cells undergo to sustain growth and division, as well as the potential therapeutic window to treat certain pathologies, with a special focus on cancer.
First Approach to the Logistic Support for the International Fusion Materials Irradiation Facility (IFMIF).
The current design of the RF power supply for the International Fusion Materials Irradiation Facility (IFMIF) is based upon tetrodes technology. Due to the improvement in the solid state amplifiers technology, the possibility of using this option for IFMIF is becoming a very competitive alternative presenting a priori several advantages in terms of availability, reliability and logistics. The current technology based on RF tetrodes chains leads no room for substantial improvements in terms of availability being the requirement for the RF system hard to achieve. On the other hand the solid state amplifiers technology opens from its concept several options to increase the system availability. ...
Immediate Struggles
Publisher description
Renzo Piano
Renzo Piano is one of the world’s greatest living architects and creator of a host of iconic modern buildings, including the Pompidou in Paris, the Menil Collection in Texas, Kansai Airport in Japan, the Shard in London and the new Whitney Museum of American Art in New York. Written and created in collaboration with the Piano Foundation in Genoa, this richly illustrated volume covers the early work as well as the most recent designs, making a complete survey of his career to date. Starting with his beginnings with the Pompidou Centre in the 1970s (in collaboration with Richard Rogers) the story continues up to construction of one of his latest works, a spectacular new bridge in Genoa in 20...
New Developments in Robotics Automation and Control
This book represents the contributions of the top researchers in the field of robotics, automation and control and will serve as a valuable tool for professionals in these interdisciplinary fields. It consists of 25 chapter that introduce both basic research and advanced developments covering the topics such as kinematics, dynamic analysis, accuracy, optimization design, modelling , simulation and control. Without a doubt, the book covers a great deal of recent research, and as such it works as a valuable source for researchers interested in the involved subjects.
