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Mitochondrial Dysfunction in Neurodegenerative Disorders
This second edition brings together up-to-date contributions from leaders in the field internationally on the various ways in which mitochondrial dysfunction contributes to the pathogenesis of neurodegenerative diseases, including Parkinson’s disease, Alzheimer’s disease and multiple sclerosis. The reader is guided through the basic functions of mitochondria and the mechanisms that lead to their dysfunction, and on to the consequences of this dysfunction for neuronal function before finishing with the modelling of these disorders and discussion of new potential therapeutic targets. Additional chapters have been added to the book to reflect advances in the field and there are many new contributors and topics, including how mitochondria are degraded and the interaction of the mitochondria with pathologically relevant proteins. Mitochondrial Dysfunction in Neurodegenerative Disorders provides an accessible, authoritative guide to this important area for neurologists; research and clinical neuroscientists; neuropathologists; and residents with an interest in clinical research.
Role of Physical Exercise in Preventing Disease and Improving the Quality of Life
The aim of this volume is to underline that promoting physical activity is crucial to preventing illness and maintaining our health, thus leading to a reduction in healthcare costs. Over the last decade studies have shown that physical exercise plays an important role in maintaining an individual's psycho-physical balance. Physical activity therefore helps in tackling today's major health challenges, including diabetes, high blood pressure, and cardiorespiratory diseases.
Redox Cell Biology and Genetics, Part B
The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today—truly an essential publication for researchers in all fields of life sciences. Protein Structure and Function Nucleic Acids and Genes
Mitochondrial DNA
This volume compiles a comprehensive range of methods to study key aspects of mitochondrial DNA including nucleoid structure and packaging, replication, genome integrity, and disease. Chapters are organized into eight methodological sections that cover in vitro and in vivo methods, including for mtDNA isolation, visualization, deep sequencing, gene editing, and diagnostic aspects of mtDNA disease. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and methods, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Mitochondrial DNA: Methods and Protocols aims to be useful and informative for researchers and clinicians with an interest in mitochondrial DNA.
Cumulative Subject Index
The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today—truly an essential publication for researchers in all fields of life sciences. Supplements index volumes 33, 75, 95, 120, 140, 175, 199, 229, 265, 285, and 320 Subject index Contributor index
Bursting with Energy
“This book could change your life. If you apply it, it will." —David Minkoff, MD, author of The Search for the Perfect Protein Learn to feel younger as you get older! Discover how to eliminate bad habits that can impair energy production and improve your overall energy and health with the groundbreaking methods in Bursting with Energy, now updated and revised in this second edition. Maintaining energy production is the key to functioning at a youthful level as we get older. Our cells extract energy from oxygen, but as we age, they become less efficient at performing this extraction. As a result, we develop the symptoms of aging: weakness, pain, disease, muscle wasting, and immune dysfunc...
