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This is the last of five books in the Amino Acids, Peptides and Proteins in Organic Synthesis series. Closing a gap in the literature, this is the only series to cover this important topic in organic and biochemistry. Drawing upon the combined expertise of the international "who's who" in amino acid research, these volumes represent a real benchmark for amino acid chemistry, providing a comprehensive discussion of the occurrence, uses and applications of amino acids and, by extension, their polymeric forms, peptides and proteins. The practical value of each volume is heightened by the inclusion of experimental procedures. The 5 volumes cover the following topics: Volume 1: Origins and Synthe...
There is little wonder in the fact that the investigation of amino acids is of fundamental interest to scientists from so many diversified fields. If amino acids were only basic constituents of enzymes as well as structural and other proteins, this property alone would elevate them to real scientific importance. Added to this role, however, is their ability to serve as building blocks for the production of many classes of secondary metabolites. They can support the biosynthesis of a myriad of natural products including nonprotein amino acids, cyanogenic glycosides, phar macologically active alkaloids, certain phenols, purines and pyrimidines, nucleic acids, condensed tannins, lignins and oth...
Amino acids are featured in course syllabuses and in project and research work over a wide spectrum of subject areas in chemistry and biology. Chemists and biochemists using amino acids have many common needs when they turn to the literature for comprehensive information. Among these common interests, analytical studies, in particular, have undergone rapid development in recent years. All other chemical and biochemical aspects of amino acids - synthesis, properties and reactions, preparation of derivatives for use in peptide synthesis, racemization and other fundamental mechanistic knowledge - have been the subject of vigorous progress. This book offers a thorough treatment of all these developing areas, and is structured in the belief that biochemists, physiologists and others will profit from access to information on topics such as the physical chemistry of amino acid solutions, as well as from thorough coverage of amino acid metabolism, biosynthesis and enzyme inhibition; and that chemists will find relevant material in biological areas as well as in the analysis, synthesis and reactions of amino acids.
This text is suitable for advanced undergraduate and beginning graduate students in chemistry and biochemistry studying amino acids and peptides. The authors concentrate on amino acids and peptides without detailed discussions of proteins, although the book gives all the essential background chemistry, including sequence determination, synthesis and spectroscopic methods, to enable the reader to appreciate protein behaviour at the molecular level. The approach is intended to encourage the reader to cross classical boundaries, as in the later chapters on the biological roles of amino acids and the design of peptide-based drugs. For example, there is a section on the enzyme-catalysed synthesis of peptides, with suitable examples, an area often neglected in texts describing peptide synthesis. This modern text will be of value in the amino acid, peptide and protein field, to advanced undergraduates, graduate students and research workers.
Contents: Amino-Acids and Proteins, Carbohydrates, Vitamins and Anthocyanidins, Some Acids and Purine Derivatives.
The Biochemistry of Plants: A Comprehensive Treatise, Volume 5: Amino Acids and Derivatives provides information pertinent to the fundamental aspects of plant biochemistry relating to the metabolism of amino acids with emphasis on amino acids present in proteins. This book discusses the metabolism of sulfur and nitrogen from the inorganic sources available to plants through their incorporation into organic compounds. Organized into 17 chapters, this volume begins with an overview of some aspects of the biochemistry of symbiotic nitrogen fixation. This text then examines the ultrastructure and metabolism of the developing nodule with particular emphasis on interactions between the host legumes and the bacterial symbiont. Other chapters consider the characteristics of the enzymes involved in nitrate and nitrite reduction. The final chapter deals with the essential roles of amino acids and other soluble nitrogenous compounds in plant metabolism. This book is a valuable resource for plant biochemists, neurobiochemists, molecular biologists, senior graduate students, and research workers.
It is a commonly held belief that athletes, particularly body builders, have greater requirements for dietary protein than sedentary individuals. However, the evidence in support of this contention is controversial. This book is the latest in a series of publications designed to inform both civilian and military scientists and personnel about issues related to nutrition and military service. Among the many other stressors they experience, soldiers face unique nutritional demands during combat. Of particular concern is the role that dietary protein might play in controlling muscle mass and strength, response to injury and infection, and cognitive performance. The first part of the book contai...
Over the last decades, amino acids have been found to be of importance in many fields of science. Apart from their biological function, this family of organic compounds has been employed in the synthesis of a vast variety of salts, with impact on areas such as materials science, pharmaceutical or physical research. This covers a wide range, from the discovery of important ferroelectrics or non-linear optical materials to nutrients, flavor enhancers or drugs. This book describes amino acids and their salts with cations, anions and inorganic compounds from a chemical, physical and crystallographical point of view. Additional data on structural properties, crystal growth and the relation of structure and physical properties of amino acid salts is discussed.
"How did life originate and why were left-handed molecules selected for its architecture?" This question of high public and interdisciplinary scientific interest is the central theme of this book. It is widely known that in processes triggering the origin of life on Earth, the equal occurrence, the parity between left-handed amino acids and their right-handed mirror images, was violated. The balance was inevitably tipped to the left – as a result of which life's proteins today exclusively implement the left form of amino acids. Written in an engaging style, this book describes how the basic building blocks of life, the amino acids, formed. After a comprehensible introduction to stereochemi...
Indispensable reference source for researchers in the pharmaceutical and allied industries, and at the biology/chemistry interface in academia.