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Leishmania Parasites
Leishmania parasites are a group of pathogens responsible for diseases known as leishmaniases. These pathologies affect predominantly the poorest people, mainly in tropical countries, exerting a high impact on mortality and morbidity rates. The absence of a vaccine and the reduced drug arsenal, associated with the diversity in the clinical presentation and hosts, highlight the complexity of the disease and its position as a worldwide public health problem. This book addresses different aspects related to leishmaniases, such as epidemiology, immunopathology, and the challenges of disease in humans and domestic animals. The information presented contributes to a better understanding of the Leishmania parasites and different clinical forms produced by infection, as well as their distribution around the world and their impacts on public health.
Leishmaniases as Re-emerging Diseases
Leishmania parasites plague the mammalian host causing high morbidity and mortality. The parasites persist in the hostile milieu, crippling its defensive arsenal. In the face of mounting resistance to an antiquated drug arsenal, new approaches are urgently desired to keep the infection at bay. Furthermore, to strengthen the leishmaniasis elimination drive, particular emphasis has to be laid on identification of new targets and vaccination strategies. This book gives a brief glimpse of the epidemiology of leishmaniasis, immune evasion, vaccination, and therapeutic modalities that may work by untangling the immunological cross-wires of pathogenic cross-talk. The Conventional treatment and its drawbacks, the prospects of phytotherapy and nanomedicines, are also discussed. The identification of drug targets with the aim of designing inhibitors is also exemplified.
Essential Oils
Essential oils were used globally as a folk medicine for the treatment of a number of diseases because of the high content of natural compounds. Therefore, this book looks at research topics dealing with isolation, purification, and identification of active ingredients of essential oils from plants. This knowledge will provide significant information about essential oils to researchers and others interested in the field.
Ginger Cultivation and Its Antimicrobial and Pharmacological Potentials
Ginger is well known as a spice and flavor. It has been a traditional medical plant in many cultures for thousands of years. To uncover the miraculous plant, this book not only gives you the plant's origins, where the plant is grown now, but also provides current studies on its utilization, cultivation, breeding, and therapeutic benefits.
Essential Oils
Over the centuries humans have used essential oils in the most diverse applications, mainly medicinal, and as sources of bioactive molecules. They have been used in different industrial sectors, such as the pharmaceutical and chemical industries, cosmetics and more recently in the food industry. Due to new research in the field of food science and technology, new sources of bioactive compounds have been described, as they have been shown to be a viable alternative for applications in biofilms, nano emulsions, natural antioxidants, control of microorganisms such as fungi, bacteria and protozoa that can be pathological for human health. The use of essential oils in food science and technology ...
Emerging and Re-emerging Infectious Diseases of Livestock
This book provides comprehensive knowledge on diseases in livestock that are caused by viruses, parasites and bacteria. Emerging and re-emerging pathogens are presented in detail for various animal groups and in-depth insights into pathogenesis and epidemiology will be provided for each of them. In addition, state-of-the-art treatment possibilities, control measures as well as vaccination strategies are discussed. The recent years have witnessed a sharp increase in the number of emerging and re-emerging infectious diseases of livestock and many of these, including Influenza, Corona and Hanta are of public health importance. The reasons for this development are manifold:changes in the climate, life cycle of vectors and increased global travel. Also, due to extensive deforestation, livestock are increasingly coming in direct contact with wild animals that are reservoirs of many emerging pathogens. Recent progress in diagnosis and management of emerging infectious diseases are also topic of this book.
Leishmaniasis
Leishmaniasis is a major global health challenge, affecting approximately 12 million of the poorest people in 100 countries. It is a deforming and fatal disease in the visceral form. Therapies for leishmaniasis are numerically restricted, basically consisting of the administration of miltefosine, pentavalent antimonials, amphotericin B, or pentamidine. This is an important vulnerability against therapy efficiency that must be overcome by the scientific community. This book discusses important aspects of the disease, such as treatment, epidemiology, and molecular and cell biology. The information contained herein is important for young researchers as they seek to develop safe and effective treatments for this neglected tropical disease.
Amyloidosis
Amyloidoses are a heterogeneous group of diverse etiology diseases. They are characterized by an endogenous production of abnormal proteins called amyloid proteins, which are not hydrosoluble, form depots in various organs and tissue of animals and humans and cause dysfunctions. Despite many decades of research, the origin of the pathogenesis and the molecular determinants involved in amyloid diseases has remained elusive. At present, there is not an effective treatment to prevent protein misfolding in these amyloid diseases. The aim of this book is to present an overview of different aspects of amyloidoses from basic mechanisms and diagnosis to latest advancements in treatment.
Periurbanização E Espaço Periurbano
Elabora-se neste livro uma leitura a respeito do espaço periurbano de Aldeia. A localidade esta localidade na franja oeste da Região Metropolitana do Recife e é palco de um intenso processo de penetração da urbanização. Ali, experimenta-se, ao longo das últimas décadas, a redução do granjismo e o fortalecimento de um modelo de urbanização marcado pela instalação de novos empreendimentos imobiliários na forma de condomínios horizontais de classe média. O resultado desse fenêmeno é a conformação de um espaço periurbano marcado pela heterogeneidade populacional, pela baixa densidade, por conflitos de ordem ambiental, por interesses imobiliários e por novos problemas. Para além de conclusões a presente obra se propõe provocar novas reflexões a respeito do processo de periurbanização e das áreas periurbanas.
Modulação da resposta imunológica de cães utilizando BCG em associação com fração flagelar de Leishmania amazonensis
A Leishmaniose Visceral Canina (LVC), do ponto de vista epidemiológico, é considerada mais importante do que a Leishmaniose Visceral Humana (LVH), pois, além de ser mais prevalente, os animais infectados apresentam intenso parasitismo cutâneo, servindo como fonte de infecção para os insetos vetores. Essas características tornam o cão doméstico o principal reservatório do parasito. A pele dos cães tem esse aspecto importante para a LV por ser a região do corpo que mais manifesta os sinais clínicos, o local onde ocorre a primeira interação entre o parasito e o sistema imunológico do cão, além de ser o local onde se encontram grandes quantidades de formas amastigotas do parasito. No entanto, a maioria dos cães infectados não apresenta sinal clínico e, mesmo na pele clinicamente sadia, pode haver a presença de parasitas, o que alerta para a importância desses animais no ciclo de transmissão da doença. Desse modo, a busca por estratégias de formulações vacinais eficazes contra a LVC, que visem à interrupção do ciclo de transmissão da doença, vem sendo investigada como medida alternativa de controle.
