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2021 WHO Classification of Pediatric Brain Tumors: A Final Wedding Between Morphology and Molecular Biology?
Tumors of the central nervous system (CNS) are a dramatic health problem due to their high morbidity and mortality in all ages. In the pediatric population, brain tumors constitute the second most common cancer diagnosed worldwide each year, accounting for approximately 25% of childhood cancers. Although there has been a moderate increase in survival rates for children with CNS tumors over the past decades, CNS tumors remain the second leading cause of cancer death in children less than 20 years of age. The fifth edition of the World Health Organization (WHO) Classification of Tumors of the Central Nervous System (WHO CNS5) was recently released. This builds on the 2016 WHO CNS tumor update,...
Robotics in Neurosurgery
This book provides a state-of-the art review of this field and demonstrates the basic applications of robotic surgery in the field of neurosurgery, exposing its basic principles, practical technical nuances, and advantages and limitations related to the technology. It also provides a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts. All chapters are written by experts in their fields and include the most up to date scientific and clinical information. Robotics in Neurosurgery: Principles and Practice will serve as a valuable resource for clinicians, surgeons, engineers and researchers dealing with, and interested in, this challenging and promising field in robotics applied to neurosurgery.
Recent Advances in Pediatric Cancer Predisposition Syndromes
We would like to acknowledge Dr. Giada Del Baldo and Dr. Mariachiara Lodi from IRCCS Bambino Gesù Children’s Hospital have acted as coordinator and have contributed to the preparation of the proposal for this Research Topic.
365 Days of Progress In Neuro-Oncology and Neurosurgical Oncology
“365 Days of Progress” is part of a wider series of Research Topics across Frontiers in Oncology, hosted by our Specialty Chief Editors, showcasing popular articles from 2021 igniting interest in the field. This Research Topic aims to highlight the work featured and spark further discussion. The Neuro-Oncology and Neurosurgical Oncology field is continuously evolving, therefore we are seeking to understand developments and perspectives on articles that have attracted attention throughout the year. We welcome Opinions, Perspectives, and Mini-Review article types to facilitate this discussion. We also welcome updated original data following the research featured in this collection. Please ...
New Frontiers in Gene-Modified T Cell Technology
The development, clinical translation and recent efficacy of novel gene therapies targeting refractory malignancies has led to research that extends this technology to a variety of infectious and rheumatological diseases. Unlike conventional drugs or antibodies, T cells have the potential to target and exert effector function in response to disease in a dynamic manner, acting as a “living drug”. The most efficacious form of gene-modified T cells to date is the chimeric antigen receptor (CAR)-modified T cell, which redirects the specificity of T cells to an antigen expressed by tumor cells. Clinical experience with autologous CAR-T cells, primarily in hematologic malignancies, has underscored the feasibility and safety of the approach, while also demonstrating dramatic and sustained antitumor effects through mechanisms orthogonal to those of traditional anticancer therapies. However, several challenging obstacles must be surmounted in order to improve the broader efficacy of this approach.
