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An unprecedented compilation of state-of-the-art advances in clinical research by premier clinical scientists around the world. This volume discusses the methods of clinical research and the interpretation of their results in studies of normal individuals, obese subjects, and patients with diabetes mellitus. Along the way, the authoritative contributors writing here illuminate how changes in the hormone action and substrate metabolism of healthy humans may lead to obesity and noninsulin-dependent diabetes mellitus.
The International Textbook of Diabetes Mellitus has been a successful, well-respected medical textbook for almost 20 years, over 3 editions. Encyclopaedic and international in scope, the textbook covers all aspects of diabetes ensuring a truly multidisciplinary and global approach. Sections covered include epidemiology, diagnosis, pathogenesis, management and complications of diabetes and public health issues worldwide. It incorporates a vast amount of new data regarding the scientific understanding and clinical management of this disease, with each new edition always reflecting the substantial advances in the field. Whereas other diabetes textbooks are primarily clinical with less focus on ...
For the 500th anniversary of Leonardo da Vinci’s death comes an immersive journey through five centuries of history to define the Leonardo mystique and uncover how the elusive Renaissance artist became a global pop icon. Virtually everyone would agree that Leonardo da Vinci was the most important artist of the High Renaissance. It was Leonardo who singlehandedly created the defining features of Western art: a realism based on subtle shading; depth using atmospheric effects; and dramatic contrasts between light and dark. But how did Leonardo, a painter of very few works who died in obscurity in France, become the internationally renowned icon he is today, with the Mona Lisa and the Last Sup...
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
El síndrome metabólico es uno de los retos más intrigantes y fascinantes de la medicina contemporánea. Se trata de una patología en la que confluyen problemas de distintas áreas de la medicina: diferentes grados de hipertensión, acumulación de grasa, insulinoresistencia, estados protrombótico y proinflamatorio, todos juntos en la misma persona. Esta concurrencia de factores hace que la persona tenga un riesgo mucho mayor de sufrir enfermedad cardiovascular o diabetes mellitus tipo 2, que lo que la suma de los factores individuales supondría. Se trata de una "enfermedad" nueva, que ha llegado a ser un problema de salud pública muy importante en las sociedades desarrolladas y cuya r...
Early Vascular Aging (EVA): New Directions in Cardiovascular Protection, Second Edition continues to be the most comprehensive and authoritative resource on premature alterations in artery structure and function. The book presents a novel approach to the problem of cardiovascular disease, showing it in relation to great vessels disease and revealing a comprehensive approach to the problem of increased rigidity of the great vessels, its causes, and further consequences. This second edition contains completely updated content with expanded coverage of basic and translational research, systematic reviews of the most prominent literature, discussion of applicability of new evidence and more. Wri...
This book provides an in-depth and up-to-date review of the association between blood pressure disorders and diabetes mellitus. In addition, it discusses the specific role of hemodynamic alterations on the vasculature of various target organs (the retina, kidney, brain, and gravid uterus), topics that are infrequently considered and or acknowledged by clinicians. Covering all aspects of the interaction between metabolic and hemodynamic factors, the book presents the diverse perspectives of the contributing authors and extensive discussions of issues including diabetic kidney disease, diabetic hypertensive phenotypes and postural hypotension.
Whether you're a seasoned randonneur or an armchair dreamer, this is the book for you. A fantastic, practical guide for any keen rider on how to complete 25 of the most famous rides across Europe.
Are you curious about the private laboratory of Giacomo Leopardi, Italy’s greatest modern lyrical poet? Interested in using expert maps to explore it, while deepening your acquaintance with one of the most creative materialist thinkers? This collection of essays makes very original use of the new translation of Leopardi’s Zibaldone di pensieri and investigates its connections to all his other works. Whether your primary interest lies in Italian literature and criticism, linguistics and poetics, the origins of genres such as the fantastic, or in philosophical queries regarding materialism and hedonism, this collection offers original research that will challenge the reader to view this outstanding intellectual in a new light. Offering some of the earliest reflections against anthropocentrism, championing the artist’s interest in the natural sciences, and questioning humanity’s purpose(s) in this world, Leopardi’s work is presented in this volume as an indispensable tool to understand the complexity of Italy’s cultural transformations between the 18th and the 19th centuries.
Not long after Martin Luther’s defiance of the Church in 1517, dialogue between Protestants and Catholics broke down, brother turned against brother, and devastating religious wars erupted across Europe. Desperate to restore the peace and recover the unity of Faith, Catholic theologians clarified and reaffirmed Catholic doctrines, but turned as well to another form of evangelization: the Arts. Convinced that to win over the unlettered, the best place to fight heresy was not in the streets but in stone and on canvas, they enlisted the century’s best artists to create a glorious wave of beautiful works of sacred art — Catholic works of sacred art — to draw people together instead of dr...