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MRNA Targeting Eliminates the Need for the Signal Recognition Particle During Membrane Protein Insertion in Bacteria
Abstract: Signal-sequence-dependent protein targeting is essential for the spatiotemporal organization of eukaryotic and prokaryotic cells and is facilitated by dedicated protein targeting factors such as the signal recognition particle (SRP). However, targeting signals are not exclusively contained within proteins but can also be present within mRNAs. By in vivo and in vitro assays, we show that mRNA targeting is controlled by the nucleotide content and by secondary structures within mRNAs. mRNA binding to bacterial membranes occurs independently of soluble targeting factors but is dependent on the SecYEG translocon and YidC. Importantly, membrane insertion of proteins translated from membrane-bound mRNAs occurs independently of the SRP pathway, while the latter is strictly required for proteins translated from cytosolic mRNAs. In summary, our data indicate that mRNA targeting acts in parallel to the canonical SRP-dependent protein targeting and serves as an alternative strategy for safeguarding membrane protein insertion when the SRP pathway is compromised
The Transformation of EU Geographical Indications Law
Linking traditional and local products to a specific area is increasingly felt as a necessity in a globalised market, and Geographical Indications (GIs) are emerging as a multifunctional tool capable of performing this and many other functions. This book analyses the evolving nature of EU sui generis GIs by focusing on their key element, the origin link, and concludes that the history of the product in the broad sense has become a major factor to prove the link between a good and a specific place. For the first time, this area of Intellectual Property Law is investigated from three different, although interrelated, perspectives: the history and comparative assessment of the systems of protec...
Cashmere
Allude is one of Germany's most illustrious labels. Since it was founded in 1993 by Andrea Karg, the company has been a key element in establishing the popularity of cashmere combining it with new designs and reaching out to a new clientele. This exceptional book introduces cashmere with its special history and the handiwork that is involved, using beautiful pictures together with a sound and comprehensive text. In addition, Allude together with the designs and the people behind this label are introduced. It is here that we hear the story of the creative process from design to the finished product, visiting fashion shows in Paris and seeing the development of the label over several years by means of a sumptuous world of images. Allude has stores and outlets in cities around the world.
Bloody Origin
From the author of ‘CROWLEY’S CULT’ (a New Apple Book Awards OFFICIAL SELECTION!). “The beast from BLOODY LEGENDS was just as evil as a boy.” A serial killer is born! BLOODY ORIGIN is the prequel to the Bloody Series, in which Dr. Daniel Cooper, a vicious serial killer, perpetrates the most heinous crimes with a truly morbid creativity. In this short story, you will learn how Daniel came to understand who he really is, and what it was like for him the first time he killed a person. Are we really born evil? Find out here, and get ready to learn how it all began! REVISED EDITION. This edition incorporates major editorial revisions, but there are no plot changes to the original story. The Bloody Series will be made up of three books, plus a prequel, each containing a stand-alone story with no major cliffhangers. However, since it is a series, for the best reading experience and to avoid spoilers this is the recommended order to read the stories in: Bloody Origin – Prequel Bloody Legends – Book 1 Bloody Puzzle – Book 2 Bloody Hunt – Book 3 WARNING: These stories contain extreme violence against people and animals, vulgar language, sex, and graphic murders.
