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General Condition and Comorbidity of Long-term Survivors of Adult Acute Lymphoblastic Leukemia
Abstract: Cure rates in adult acute lymphoblastic leukemia (ALL) improved using pediatric-based chemotherapy and stem cell transplantation (SCT). However, limited data on the health condition of cured adults are available whereas pediatric data cannot be transferred. The GMALL analyzed the health status in survivors of adult ALL retrospectively. Physicians answered a questionnaire on general condition (Eastern Cooperative Oncology Group [ECOG] status) and comorbidity or syndrome occurrence observed after treatment. Five hundred and thirty-eight patients with a median age of 29 (range, 15-64) years at diagnosis were analyzed, median follow-up was 7 (range, 3-24) years. Thirty-one percent had received SCT. ECOG status was 0-1 in 94%, 34% had not developed significant comorbidities. Most frequent comorbidities involved the neurologic system (27%), endocrine system (20%), skin (18%), graft-versus-host-disease (15%), cardiac system (13%), fatigue (13%). SCT impacted ECOG status and comorbidity occurrence significantly. ECOG 0-1 was observed in 86% of SCT and 98% of non-SCT patients (P
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Dynamics of Multibody Systems
This enhanced fourth edition of Dynamics of Multibody Systems includes an additional chapter that provides explanations of some of the fundamental issues addressed in the book, as well as new detailed derivations of some important problems. Many common mechanisms such as automobiles, space structures, robots and micromachines have mechanical and structural systems that consist of interconnected rigid and deformable components. The dynamics of these large-scale multibody systems are highly nonlinear, presenting complex problems that in most cases can only be solved with computer-based techniques. The book begins with a review of the basic ideas of kinematics and the dynamics of rigid and deformable bodies before moving on to more advanced topics and computer implementation. The book's wealth of examples and practical applications will be useful to graduate students, researchers and practising engineers working on a wide variety of flexible multibody systems.
Modern Operating Systems
The widely anticipated revision of this worldwide best seller incorporates the latest developments in operating systems technologies. Hundreds of pages of new material on a wealth of subjects have been added. This authoritative, example-based reference offers practical, hands-on information in constructing and understanding modern operating systems. Continued in this second edition are the "big picture" concepts, presented in the clear and entertaining style that only Andrew S. Tanenbaum can provide. Tanenbaum's long experience as the designer or co-designer of three operating systems brings a knowledge of the subject and wealth of practical detail that few other books can match. FEATURES\ N...
History of the Anderson Family
John Anderson Kåsa was born in Norway in 1808. He married Kjersti Andersdatter Jöntvedt in 1831 and they had eight children. John also had an illegitimate child born in 1830. John and Kjersti came America in 1853 with most of their family and settled in Wisconsin. Sketches and material on many of their descendants are included. Descendants and relatives live mainly in the northern midwestern states.
Communication in Turbulent Times
This book is characterised by a broad approach towards corporate communication, emphasising change and crisis. The focus is not on crises as an exceptional situation but rather on broader volatility in the environment. The purpose of this book is to increase the understanding of multi-stakeholder communication concerning organisational issues and crises. From the perspective of organisational management, this book clarifies how communication contributes to organisational resilience—the ability to adapt to a changing environment and mitigate emergency crises. In todays’ world, change is not the exception but a constant presence. Moreover, issues and risks occur that may grow to become crises. Coping with change and unexpected events, is what the concept of ‘resilience’ is about. Organisational resilience is the basis for the long-term viability of organisations in a turbulent environment. Communication, in various ways, is a bridging activity that supports the capacity of the organisation to function despite risks and disruptive incidents.
Modern Operating Systems
An up-to-date overview of operating systems presented by world-renowned computer scientist and author, Andrew Tanenbaum. This is the first guide to provide balanced coverage between centralized and distributed operating systems. Part I covers processes, memory management, file systems, I/O systems, and deadlocks in single operating system environments. Part II covers communication, synchronization process execution, and file systems in a distributed operating system environment. Includes case studies on UNIX, MACH, AMOEBA, and DOS operating systems.
Yale Law School
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