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General Condition and Comorbidity of Long-term Survivors of Adult Acute Lymphoblastic Leukemia
Abstract: Cure rates in adult acute lymphoblastic leukemia (ALL) improved using pediatric-based chemotherapy and stem cell transplantation (SCT). However, limited data on the health condition of cured adults are available whereas pediatric data cannot be transferred. The GMALL analyzed the health status in survivors of adult ALL retrospectively. Physicians answered a questionnaire on general condition (Eastern Cooperative Oncology Group [ECOG] status) and comorbidity or syndrome occurrence observed after treatment. Five hundred and thirty-eight patients with a median age of 29 (range, 15-64) years at diagnosis were analyzed, median follow-up was 7 (range, 3-24) years. Thirty-one percent had received SCT. ECOG status was 0-1 in 94%, 34% had not developed significant comorbidities. Most frequent comorbidities involved the neurologic system (27%), endocrine system (20%), skin (18%), graft-versus-host-disease (15%), cardiac system (13%), fatigue (13%). SCT impacted ECOG status and comorbidity occurrence significantly. ECOG 0-1 was observed in 86% of SCT and 98% of non-SCT patients (P
Green Approaches in Medicinal Chemistry for Sustainable Drug Design
Extensive experimentation and high failure rates are a well-recognised downside to the drug discovery process, with the resultant high levels of inefficiency and waste producing a negative environmental impact. Sustainable and Green Approaches in Medicinal Chemistry reveals how medicinal and green chemistry can work together to directly address this issue. After providing essential context to the growth of green chemistry in relation to drug discovery in Part 1, the book goes on to identify a broad range of practical methods and synthesis techniques in Part 2. Part 3 reveals how medicinal chemistry techniques can be used to improve efficiency, mitigate failure and increase the environmental benignity of the entire drug discovery process, whilst Parts 4 and 5 discuss natural products and microwave-induced chemistry. Finally, the role of computers in drug discovery is explored in Part 6. Identifies novel and cost effective green medicinal chemistry approaches for improved efficiency and sustainability Reflects on techniques for a broad range of compounds and materials Highlights sustainable and green chemistry pathways for molecular synthesis
Schreibzauber
In der Anthologie "Schreibzauber" sind Werke zusammengefasst, die die Autoren/Innen des gleichnamigen Autorenkreises geschrieben haben. Der Autorenkreis gründete sich im Mai 2008 und besteht aus sechs Mitgliedern. Den geschriebenen Wörtern verbunden, treffen sie sich einmal im Monat. Ihr Ziel: Ideen zu Papier bringen. Aus ihrem umfangreichen Vorrat an Prosatexten und Lyrikwerken wurden Auswahlen getroffen, die in dieser Anthologie zum ersten Mal erscheinen.
Roster of Members
None
Index Medicus
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
