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Carbonic Anhydrase
Carbonic Anhydrase: Its Inhibitors and Activators provides a state-of-the-art overview of the latest developments and challenges in carbonic anhydrase research. Authors describe the mechanisms of action of specific inhibitors in relation to physiological function, and present previously unpublished research on CA activators. Written by a team of in
Carbonic Anhydrase
Carbonic Anhydrase: Its Inhibitors and Activators provides a state-of-the-art overview of the latest developments and challenges in carbonic anhydrase research. Authors describe the mechanisms of action of specific inhibitors in relation to physiological function, and present previously unpublished research on CA activators. Written by a team of in
Carbonic Anhydrase: Mechanism, Regulation, Links to Disease, and Industrial Applications
The study of carbonic anhydrase has spanned multiple generations of scientists. Carbonic anhydrase was first discovered in 1932 by Meldrum and Roughton. Inhibition by sulfanilamide was shown in 1940 by Mann and Keilin. Even Hans Krebs contributed to early studies with a paper in 1948 showing the relationship of 25 different sulfonamides to CA inhibition. It was he who pointed out the importance of both the charged and uncharged character of these compounds for physiological experiments. The field of study that focuses on carbonic anhydrase (CA) has exploded in recent years with the identification of new families and isoforms. The CAs are metalloenzymes which are comprised of 5 structurally d...
Perspectives in Bioremediation
Bioremediation - the use of microorganisms for environmental clean-up - is a technology that is experiencing a rapid phase of development. The authors of this text an understanding of the current progress and limitations of technologies that are designed to help nature herself.
Enzymes and Their Inhibitors
Focusing on the development of enzyme inhibitors as therapeutic drugs, Enzymes and Their Inhibitors: Drug Development provides a concise overview of the chemistry of major types of enzymes and their inhibitors. The opening chapters introduce readers to the structure, functions, mechanisms, and kinetics of enzymes, including their use as disease mar
Drug Design of Zinc-Enzyme Inhibitors
Brings together functional and structural informationrelevant to the design of drugs targeting zinc enzymes The second most abundant transition element in living organisms, zinc spans all areas of metabolism, with zinc-containing proteins offering both established and potential drug targets. Drug Design of Zinc-Enzyme Inhibitors brings together functional and structural information relevant to these zinc-containing targets. With up-to-date overviews of the latest developments field, this unique and comprehensive text enables readers to understand zinc enzymes and evaluate them in a drug design context. With contributions from the leaders of today's research, Drug Design of Zinc-Enzyme Inhibi...
Advances in Bioscience and Biotechnology Research
Advances in Bioscience and Biotechnology Research is more inclined towards interdisciplinary studies. Recent developments in the technologies have led to a better understanding of living systems and this has removed the demarcations between various disciplines of life sciences. A new trend in life science incorporates Bitechnology and biological research involving a merger of diverse disciplines such as Isothermal Amplification Methods, A Comprehensive Review on Bioactive and Therapeutic Potential of Indian Nutmeg Myristica fragrans (Houtt), Plant Metabolic Engineering: Extension and Novel Pathway Engineering, Plant Mucilages and their Potential Applications – A Review, Microbial Biofuels ...
The Carbonic Anhydrases
Carbonic anhydrase (CA) is a seemingly ubiquitous enzyme of profound physiological importance, which plays essential roles in respiration, acid-base homeostasis, bone resorption, calcification, photosynthesis, several biosynthetic pathways and a variety of processes involving ion, gas and fluid transfer. This enzyme, which is present in at least three gene families (a, ß, ?), has found favour as a model for the study of evolution of gene families and for site-directed mutagenesis in structure/function relationships, for protein folding and for transgenic and gene target studies. Since the early use of CA inhibitors as diuretics and in treating congestive heart failure, the enzyme has been target of considerable clinical attention. Much of this is now focused on endeavours to produce a new generation of such drugs for the effective treatment of glaucoma and other potential applications. Recent data, suggesting links between CA and various disease processes, including cancer, have stimulated further...
Perspectives in Bioremediation
Bioremediation - the use of microorganisms for environmental clean-up - is a technology that is experiencing a rapid phase of development. From the opening chapter of Perspectives in Bioremediation, on the nature of environmental site assessment, on to the genetic manipulation of native soil microorganisms, the international collection of authors provide an understanding of the current progress and limitations of technologies that are designed to help nature herself. The book draws together many different aspects of environmental remediation: the environmental engineer is introduced to the bacteria of contaminated environments and the ideas developing from genetic engineering; the environmental microbiologist can grasp site assessment and the predictive kinetic analysis of potentials. The book provides a clear and concise introduction to the nature of and potential for bioremediation to contribute to a critical global effort in eliminating contamination of the world's resources and to start to reverse decades of environmental mismanagement and neglect.
