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This book provides a cutting-edge review of polyglutamine disorders. It primarily focuses on two main aspects: (1) the mechanisms underlying the pathologies’ development and progression, and (2) the therapeutic strategies that are currently being explored to stop or delay disease progression. Polyglutamine (polyQ) disorders are a group of inherited neurodegenerative diseases with a fatal outcome that are caused by an abnormal expansion of a coding trinucleotide repeat (CAG), which is then translated in an abnormal protein with an elongated glutamine tract (Q). To date, nine polyQ disorders have been identified and described: dentatorubral-pallidoluysian atrophy (DRPLA); Huntington’s dise...
Distils the most valuable discoveries in dementia research into clear, insightful chapters written by international experts.
In this work, Claudio Guillen meditates on the elusive field of comparative literature and its vicissitudes since the early 19th century.
An in-depth look at how Machado de Assis affirms his uniqueness through the role of a reflective reader who eventually becomes a self-reflective author, whose text is primarily the written memory of his private library
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This volume covers the latest methods used in clinical neurochemistry laboratories for both clinical practice and research. Chapters in this book discuss topics such as techniques for cerebrospinal fluid (CSF) collection, pre-analytical processing, and basic CSF analysis; an examination of biomarkers including ELISA and automated immunochemical assays for amyloid and tau markers for Alzheimer’s disease; the analysis of neurofilaments by digital ELISA; and an example of successful novel immunoassay development. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and thorough, Cerebrospinal Fluid Biomarkers is a valuable resource for clinicians and researchers to use in CSF labs and CSF courses.
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The beginning of a legacy to never be forgotten. It is the starting point of who you are. It is the examination of where you come from. Composed of characters, personalities, a climax or two... you know the things that explain why y'all, as a family, think the way y'all think and act the way y'all act. This is your story. Your family's story.
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