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Computational Modeling and Machine Learning Methods in Neurodevelopment and Neurodegeneration: from Basic Research to Clinical Applications
Computational models and machine-learning methods are increasingly valuable tools to shed light on the dynamics that govern information processing in the nervous system, as well as their disruption in pathological conditions. A variety of techniques has been used to understand how networks of neurons in the brain encode, elaborate and transmit information about the external world, and how this information influences decision-making and behavior. Structural and functional abnormalities in the above-mentioned networks can lead to a wide range of brain disorders. Recent advances in brain simulation and machine-learning techniques, together with progress in the neuroimaging field, have been essential for bridging the different spatial scales in the brain and uncovering the processes underlying cognitive, motor and behavioral impairment in neurodevelopmental and neurodegenerative disorders.
Neuromuscular Imaging
Neuromuscular imaging has increasingly become an important tool in the detection and diagnosis of inherited and acquired neuromuscular disease. This book is a groundbreaking radiological and neurological overview of current methods and applications of imaging—including aspects of neuroimaging and musculoskeletal imaging—in patients with inherited, metabolic, and inflammatory muscle diseases. Imaging features are discussed in the context of clincial presentation, histopathology, therapeutic options and differential diagnosis. World leading expert contributors give a comprehensive and didactic review of neuromuscular disorders and available imaging modalities, each illustrated with numerous figures. Topics discussed include: -Modalities such as ultrasound, CT and MRI -Muscle anatomy and physiology -Clinical applications in hereditary and acquired myopathies -Clinical applications in motor neuron disorders and peripheral nerve imaging
Acquired Neuromuscular Disorders
This book provides a state-of-the-art overview of the pathogenesis, diagnosis, and treatment of a range of inflammatory, autoimmune, and idiopathic disorders. The opening section covers clinical tools with a particular focus on the role of electromyography and MRI imaging. The second section then presents the differential diagnosis of acquired myopathies based on clinical, electrophysiological, muscle biopsy, and serological criteria, discussing in detail relevant clinical conditions such as including myasthenia gravis, polymyositis, and statin myopathies. The third section examines acute and chronic immune-mediated neuropathies, multifocal motor neuropathies, amyotrophic lateral sclerosis, paraneoplastic diseases, and diabetic polyneuropathy, offering clear guidance on available treatments and descriptions of the latest advances in immunotheraphy, drug therapy, and physiotherapy. This clinically oriented book also includes numerous illustrative figures and contributions by international authors from leading centers.
Computational Diffusion MRI
This book gathers papers presented at the Workshop on Computational Diffusion MRI, CDMRI 2020, held under the auspices of the International Conference on Medical Image Computing and Computer-Assisted Intervention (MICCAI), which took place virtually on October 8th, 2020, having originally been planned to take place in Lima, Peru. This book presents the latest developments in the highly active and rapidly growing field of diffusion MRI. While offering new perspectives on the most recent research challenges in the field, the selected articles also provide a valuable starting point for anyone interested in learning computational techniques for diffusion MRI. The book includes rigorous mathemati...
Ocular Motor and Vestibular Function in Neurometabolic, Neurogenetic, and Neurodegenerative Disorders
Eye movements provide rich source of information about brain functioning for neurologists and neuroscientists. They provide diagnostic clues, define, and localize motor and cognitive disorders. Objective eye movement assessments associated with clinical observation and genetic testing in neurodegenerative, neurometabolic, and neurogenetic diseases provide insight into their pathophysiology and disease mechanism. Finally the eye movements may be used for testing and following the response to therapies. The concrete value of studying eye movement stems from a number of advantages compared to the study of movements of axial or limb muscles. The eye movements are accessible to clinical inspectio...
Effects of Cancer Treatment on the Nervous System, Volume 2
Cancer is often associated with pain and is a frequent issue in patients with chemotherapy-induced neuropathy. The participation of patients in studies and their influence on study design is important. Patient support groups have been formed for several forms of cancer, and are helpful in dispensing advice. The treatment of cancer patients must include activities of daily living and quality of life. Often, palliative care and end-of-life care are part of the disease trajectory. As this book shows, patients do not have equal access to cancer treatment around the world, and often basic issues as diagnosis, treatment are lacking.
Diagnostic Imaging
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