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Membrane Transporters and Channels as Targets for Drugs
Transporters and channels are membrane proteins that mediate the traffic of metabolites, water and ions across biological membranes. Membrane transport proteins are crucial to maintain homeostasis and assure cell survival upon intracellular or environmental stress. A failure of any of these transport systems may have dramatic consequences for cell function. There is increasing evidence that membrane transport proteins play important functions in healthy conditions and that their absence or dysfunction may cause diseases. In recent years much attention has been paid to diseases resulting from defective transporters (“carrier diseases”) and ion channels (“channelopathies”). Very intere...
Cellular Oxidative Stress
This book collects 17 original research papers and 9 reviews that are part of the Special Issue “Cellular Oxidative Stress”, published in the journal Antioxidants. Oxidative stress on a cellular level affects the function of tissues and organs and may eventually lead to disease. Therefore, a precise understanding of how oxidative stress develops and can be counteracted is of utmost importance. The scope of the book is to emphasize the latest findings on the cellular targets of oxidative stress and the potential beneficial effect of antioxidants on human health.
Generation and Applications of Extra-Terrestrial Environments on Earth
This book has been prepared under the auspice of the European Low Gravity Research Association (ELGRA). The main task of ELGRA is to foster the scientific community in Europe and beyond in conducting gravity and space-related research.This publication is dedicated to the science community, and especially to the next generation of scientists and engineers interested in space research and in the means to use Earth to reproduce the space environment. ELGRA provides a comprehensive description of space conditions and the means that have been developed on Earth to perform space environmental and (micro-) gravity related research. .The book covers ground-based research instruments and environments...
Aquaporin Regulation
Aquaporin Regulation, Volume 112, the latest release in the Vitamins and Hormones series, highlights new advances in the field, with this new volume presenting interesting chapters highlighting Perspectives on the evolution of aquaporin superfamily, Structure and dynamics of aquaporin-1, Selectivity and Transport in Aquaporins from Molecular Simulation Studies, Aquaporin regulation in metabolic organs, Phosphorylation of human AQP2 and its role in trafficking, Regulation of Aquaporin-2 by RNA Interference, Aquaporin Regulation: Lessons from Secretory Vesicles, CFTR Regulation of Aquaporin-mediated Water Transport, Glucocorticoid Gene Regulation of Aquaporin-7, and much more.
Lung Inflammation in Health and Disease, Volume I
Respiratory diseases are leading causes of death and disability globally, with about 65 million people suffering from COPD, and 334 million from asthma, the most common chronic disease. Each year, tens of millions of people develop and can die from from respiratory infections such as pneumonia and TB. Systemic inflammation may induce and exacerbate local inflammatory diseases in the lungs, and local inflammation can in turn cause systemic inflammation. There is increasing evidence of the coexistence of systemic and local inflammation in patients suffering from asthma, COPD, and other lung diseases, and the co-morbidity of two or more local inflammatory diseases often occurs. For example, rhe...
Il figlio invisibile
E' la storia di un uomo, figlio unico, incastrato nelle relazioni disfunzionali della famiglia. Sin da bambino, si potrebbe dire "è uno a cui non manca niente". ma ha una madre, che pur vivendo per lui, perde di vista il figlio reale, mossa dal bisogno di realizzare, attraverso il figlio, sogni e progetti propri; ed un padre che inconsapevolmente lo usa per dare libero sfogo al malcontento e alle rivendicazioni che lo animano da sempre. I rapporti si complicano col tempo. E oltrepassano il "tempo del figlio", mostrando come il disagio psicologico si possa trasferire da una generazione all'altra.
Pulmonary Vasculature Redox Signaling in Health and Disease
The main goal of this book is to form a high-quality platform in which well-known and emerging pioneering basic, translational and clinical scientists can present their latest, exciting findings in the studies of redox signaling in the pulmonary vasculature. Content from outstanding investigators with unique expertise and skills of molecular and cell biology, biochemistry, physiology, pharmacology, biophysics, biotechnology and medicine will update our current out-of-date concepts with new knowledge. Rapidly increasing scientific studies have gathered a large volume of novel and important information on redox signaling in healthy and diseased pulmonary vasculature. This volume covers the nee...
Piume di struzzo
Sono passati vent'anni da quando Tina ha calcato per la prima volta il palco di "Uomini e Donne". Nessuno immaginava che dietro quella vamp esuberante, avvolta in un boa di piume di struzzo, si celasse una timida bambina del viterbese, cresciuta in una vecchia casa dal grande camino per riscaldare l'inverno e un fontanone in cortile per lavare i panni e rinfrescarsi d'estate. Nata in una famiglia umile ma dal cuore grande, Tina ha l'animo pieno di sogni. Fin da piccola, lascia che la fantasia la porti lontano dalle belle campagne di Castel di Guido fino ai locali più alla moda, immaginando di frequentare le dive che ammira per sfuggire ai pregiudizi della gente sulle sue modeste origini: Gr...
