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The Interferons
At long last, the first book to cover all important areas of interferon science in one volume. Top scientists, including many pioneers in the field, highlight the role of interferons as research tools and as therapeutic agents in clinical applications. Edited by an experienced interferonologist, chapters include discussions of interferon genes, Type I, II and III IFNs, as well as their induction, production and purification, receptors actions, measuring IFN activities and anti-IFN antibodies, as well as the evolution of viral defense mechanisms. For immunologists, cancer researchers, medicinal chemists, cell biologists, developmental biologists and the pharmaceutical industry.
Detection and Quantification of Antibodies to Biopharmaceuticals
The definitive book on the neutralization of recombinant biopharmaceuticals Recombinant biopharmaceuticals are an important tool for treating a range of illnesses; however, their efficacy can be severely impaired by their immunogenicity. When introduced into the body, these pharmaceuticals can cause the immune system to produce anti-drug antibodies (ADAs) that neutralize their effects. The first and only book to cover neutralization in connection with biopharmaceuticals and the measurement and application of neutralizing antibodies in modern medicine at any real length, Detection and Quantification of Antibodies to Biopharmaceuticals: Practical and Applied Considerations offers a comprehensi...
Therapeutic Modulation of Cytokines
Cytokines are peptide or protein cell-to-cell signaling molecules that play vital roles in normal cell and tissue homeostasis, as well as in responses to infectious agents. Because of their importance in virtually all forms of pathology, the pharmaceutical industry is devoting great effort to develop methods for the control of cytokine synthesis or action. This is the first volume to bring together experts from academia and the pharmaceutical industry to discuss problems and solutions in the therapeutic control of cytokines. An introductory section reviews the biology, physiology, and pathology of cytokines. Internationally recognized scientists then discuss the development of low molecular ...
Drug Testing In Vitro
Here, expert scientists from industry and academia share their knowledge on the assembly of functional human tissues in vitro and how to design drug screenings predictive of human exposure. In so doing, they combine the latest technological developments with strategic outlooks, such as novel cell and tissue systems for drug screening and testing, as well as emerging in vitro culture technologies. Equally importantly, the book does not shy away from regulatory acceptance and ethical issues.
Breast-Feeding: Early Influences on Later Health
Breast-Feeding: Early Influences on Later Health is a new book which draws together areas of research in early lifel programming of adult health, with a unique focus on the post-natal period in terms of early life programming particularly the extent to which differences in infant feeding practices can lay an indelible imprint on metabolism and behaviour, and hence affect later function and risk of disease. This is an area where there is much less information currently available than there is for fetal programming, and the book raises many new questions and highlights numerous areas where further research is needed. The book chapters are arranged in three core sections: Chapters 1-4 lay down ...
Interferons
Interferons documents the proceedings of a major international conference on Chemistry and Biology of Interferons: Relationship to Therapeutics held at Squaw Valley, California, in March 1982. The meeting was one of the 1982 UCLA Symposia on Molecular and Cellular Biology organized through the Molecular Biology Institute of the University of California at Los Angeles. The book is organized into four parts. Part I presents papers on recombinant DNA production of interferon. It includes studies on the synthesis of human immune interferon in E. coli and monkey cells; the expression of human ß interferon gene in heterologous cells; and the molecular activities of recombinant and hybrid leukocyt...
Immunobiology of HLA
The Tenth International Histocompatibility Workshop of this work, and Fran Berman for her help in preparing component concerning T-cell recognition of HLA class the report. MaryAnn Barletta, Sally Krell, and Halina II molecules drew its strength from the hard work, Korsun provided invaluable help with a multitude of diligence, and selfless spirit of the 23 participating organizational and operational issues. Bo Dupont and laboratories. The enthusiasm and camaraderie exhib Bob Knowles provided sound advice, helpful discus ited by the participants in Princeton during November sions, and continued support. John Hansen, Jean Marc 1987 bear testimony to the caliber of the individuals Lalouel, and...
Relations. Beyond Anthropocentrism. Vol. 1, No. 2 (2013). Inside the Emotional Lives of Non-human Animals: Part II
Relations. Beyond Anthropocentrism is a peer-refereed journal of trans-anthropocentric ethics and related inquires. The main aim of the journal is to create a professional interdisciplinary forum in Europe to discuss moral and scientific issues that concern the increasing need of going beyond narrow anthropocentric paradigms in all fields of knowledge. The journal accepts submissions on all topics which promote European research adopting a non-anthropocentric ethical perspective on both interspecific and intraspecific relationships between all life species – humans included – and between these and the abiotic environment.
ICA Health Summary
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Verde Valley
This book celebrates the colorful history of the Verde Valley from its prehistoric settlements to the Arizona State Centennial Celebration in 2012. Located in the heart of Arizona, between the Sonoran Desert and the mountain highlands of the Colorado Plateau, the Verde Valley has been a pleasant refuge for man and beast for thousands of years. In a land known for its lack of water, the Verde River and its tributaries--Clear Creek, Beaver Creek, Oak Creek, and Sycamore Creek--have attracted prehistoric people and American pioneers alike. This book will illustrate the history of the "Verde" from the ruins of the lost civilization to the first Anglo farming efforts along Clear Creek and the military presence at Camp Verde. It will illustrate the settlements at Middle Verde and along Beaver Creek, Rimrock, Oak Creek, Cornville, and Sedona. Finally, it will visit the settlement near the Cottonwoods, the exploitation of the Billion Dollar Copper Camp at Jerome, the smoke-belching furnaces of the smelters, and the elegant architecture of the planned company town of Clarkdale.
