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Hepatocellular carcinoma: from personalized medicine to practical guidelines
Hepatocellular carcinoma (HCC) is the most common primary liver cancer. HCC is the fourth cause of cancer-related mortality and the fifth most common cancer in the world. The prognosis and survival of patients depend mainly on the cancer stage at time of diagnosis. Earlier detection of the disease has seen improvement in treatment and disease-free survival over the last several decades. Currently, the only curable treatment for HCC is tumor resection or transplantation. These measures are strictly successful only if caught during early-stage HCC. Research has identified multiple molecular pathways involved in HCC on genetic, epigenetic, and proteomic levels. There has been a lot of research into designing drugs to specifically target these molecular pathways affected in patients, and thus contributing to personalized medical treatment. There is abundant bioinformatic research to document the extensive molecular pathways involved as well as drug docking techniques used to assess drug candidates for treating those affected pathways. These bioinformatic techniques result in identifying candidates suitable for further analysis in tissue and animal models and human trials.
Impending Inquisitions in Humanities and Sciences
In an era of increasing specialization, the need for cross-disciplinary dialogue demands an integrated approach that transcends the artificial boundaries between disciplines. "Impending Inquisitions in Humanities and Sciences" presents a groundbreaking tapestry of cutting-edge research across the spectrum of humanities and sciences. This volume presents a meticulously curated selection of research papers presented at the conference, a forum where scholars from diverse fields – English, Mathematics, Physics, and Chemistry – converged to engage in rigorous dialogue and push the boundaries of knowledge. From the nuanced interpretations of literary texts to the elegant formulations of mathematical models, from the awe-inspiring revelations of physics to the meticulous experiments of chemistry, each contribution challenges assumptions and provokes fresh perspectives. This collection serves as a valuable resource for scholars, students, and academic fraternity with an insatiable curiosity about the world around us.
Computer-Assisted Analysis for Digital Medicinal Imagery
The constantly evolving healthcare industry has experienced tremendous technological advancements that have significantly revolutionized medical imaging. However, with the increasing volume and complexity of medical image data, existing analysis methods must also be updated to be efficient and accurate. This is where the challenge lies—a need for a comprehensive solution that bridges the gap between cutting-edge technology and effective healthcare delivery. Computer-Assisted Analysis for Digital Medicinal Imagery offers a roadmap for navigating the intricate landscape of digital medicinal imagery analysis. Unlocking the power of machine learning and breaking down the basics provides researchers, clinicians, and students with the tools necessary to harness technology and improve healthcare outcomes.
Formal Methods and Software Engineering
This volume contains the proceedings of the 2003 International Conference on Formal Engineering Methods (ICFEM 2003). The conference was the ?fth in a series that began in 1997. ICFEM 2003 was held in Singapore during 5–7 November 2003. ICFEM 2003 aimed to bring together researchers and practitioners from - dustry, academia, and government to advance the state of the art in formal engineering methods and to encourage a wider uptake of formal methods in industry. The Program Committee received 91 submissions from more than 20 co- tries in various regions. After each paper was reviewed by at least three referees in each relevant ?eld, 34 high-quality papers were accepted based on originality...
The Bloomsbury Research Handbook of Indian Philosophy and Gender
'How do gender constructions transform religious experiences?' 'What is the role of bodily materiality in ethics and epistemology?' 'How does rethinking gender and sexuality force us to reconceptualise settled ontological frameworks?' This collection provides the first research resource to Indian philosophical gender issues, exploring a variety of texts and traditions from Indian philosophy where the treatment of gender is dynamic and diverse. Organised around three central themes - the gender dynamics of enlightenment in the Hindu and Buddhist traditions; the simple binary opposition of genders in Indian traditions; the ways in which symbolic representations of gender differ from social rea...
