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In World History, History of Islam is a glorious chapter. In fact, Muslim History involves the history of the Islamic faith as a religion and as a social institution. Through various periods, Islam made many a long stride and its influence spread far-off over the globe. Apart from religion, Muslims made considerable contribution in areas, like philosophy, literature, arts, law, economy, science, medicine and commerce etc. At the academic level, Muslim philosophers, educationists and experts of Islamic law have made great contributions. The evolution of Islam has impacted the political, economic and military history of an enormous geographical region. A century after the demise of Prophet Muh...
Multiple myeloma (MM) is a malignant neoplasm of plasma cells that accumulate in bone marrow, leading to bone destruction and marrow failure. It accounts for approximately 1.8% of all hematologic and solid cancers and slightly > 15% of hematologic malignancies in the United States. MM is typically sensitive to different classes of cytotoxic drugs, both as frontline treatment and as treatment for relapsed disease. Unfortunately, even if responses are typically durable, nowadays MM is not considered curable with current approaches. However, MM survival rates have been brilliantly improved thanks to the introduction of novel agents: patients diagnosed after 2010 have had higher rates of novel therapy use and better survival outcomes compared with those of earlier years. Most relevant therapeutic advances over the past decades has been the introduction of novel therapies, such as immune-modifying agents (thalidomide and lenalidomide) and proteasome inhibitors (bortezomib), adopted with or without stem cell transplantation.
This book offers unique content for both basic and clinical scientists around the world with an interest in cell-surface peptidases. The book focuses on five cell-surface peptidases, namely neutral endopeptidase (NEP)/CD10, aminopeptidase N (APN)/CD13, aminopeptidase A (APA)/BP1, dipeptidyl peptidase IV (DPPIV)/CD26, and placental leucine aminopeptidase (PLAP)/insulin-regulated aminopeptidase (IRAP), which are members of the type II membrane-bound peptidase family. It reviews the recent progress in these peptidases as well as their peptide substrates, and explores their physiological and pathological significance. Key features include: a new insight into the regulation of blood pressure and peripheral vascular systems; research into a new mechanism for insulin-responsive glucose transport and its application for the treatment of diabetes; and understanding of the new mechanisms of cell-survival peptidase involvement in human tumor progression
Genomics in Endocrinology focuses on exciting new advances in endocrinology resulting from DNA microarray studies and includes a comprehensive introduction to the use of DNA microarrays in endocrinology. The text provides the basis for further understanding of the usefulness of microarray analyses in endocrinology research. Topics discussed include the methodology of DNA microarrays and general methods for the analysis of microarray data.
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This book presents paraproteinemia and the highly complex scientific information behind it to clinicians in a way they can understand and, ultimately, apply to their diagnostic and treatment practices. Paraproteinemia or dysproteinemia is characterized by the overproduction of an immunoglobulin by clonal expansion of cells from the B cells lineage which includes the plasma cells. The resultant monoclonal protein can be composed of the entire immunoglobulin or of its components. The identification and categorization of the different representatives of this group of disorders have traveled a long distance, but despite its high prevalence there is surprisingly limited evidence, in some areas, t...
History of Indian Nation India, the cradle for one of the most ancient civilizations in the world, has a long and rich history, spanning thousands of years. In fact, the history of India begins with evidence of human activity millions of years ago. The Indus Valley Civilization was the first major civilization. Vedic Civilization witnessed the rise of major polities. Almost the whole country was controlled by Mauryan Empire and it was again united under Gupta Empire. Muslim rule in the subcontinent began when the Arabs conquered Sindh and Multan. Then, several invasions from Central Asia led to the formation of Muslim empires, such as the Delhi Sultanate and the Mughal Empire. Mughals conque...
About the book History of Indian Nation India, the cradle for one of the most ancient civilizations in the world, has a long and rich history, spanning thousands of years. In fact, the history of India begins with evidence of human activity millions of years ago. The Indus Valley Civilization was the first major civilization. Vedic Civilization witnessed the rise of major polities. Almost the whole country was controlled by Mauryan Empire and it was again united under Gupta Empire. Muslim rule in the subcontinent began when the Arabs conquered Sindh and Multan. Then, several invasions from Central Asia led to the formation of Muslim empires, such as the Delhi Sultanate and the Mughal Empire....