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Minimal Residual Disease in Acute Leukemia
The objective of the treatment of acute leukemia involves the eradication of all neoplastic cells, including the last one. Ideally, treatment should be controlled by monitoring cell kill. If the last cells could be discovered and their biological properties be determined, the qualitative and quantitative effects of treatment should be directly evaluable. This should ultimately permit a calculated tumor cell reduction thereby avoiding overtreatment and excessive toxicity and thus providing a basis for individualized antileukemic treatment. In recent years several new developments have contributed to the selective discovery of minimal numbers of leukemic cells which are hidden among the normal...
Minimal Residual Disease in Acute Leukemia 1986
Relapse of leukemia following successful remission-induction therapy remains a major obstacle in the treatment of patients with acute leukemia. Leukemia recurs most frequently in patients with acute myeloblastic leukemia (AML) and high risk acute lymphoblastic leukemia (ALL) following chemotherapy and less often in patients with low risk ALL and particularly in patient groups> submitted to allogeneic marrow transplantation. ' It is likely that the great majority of these recurrences originate from residual leukemic cells that survive initial remission-induction chemotherapy. Today, several research groups throughout the world place emphasis on studies concerned with the detection and treatme...
Applied Mathematics, Modeling and Computer Simulation
Applied mathematics, together with modeling and computer simulation, is central to engineering and computer science and remains intrinsically important in all aspects of modern technology. This book presents the proceedings of AMMCS 2022, the 2nd International Conference on Applied Mathematics, Modeling and Computer Simulation, held in Wuhan, China, on 13 and 14 August 2022, with online presentations available for those not able to attend in person due to continuing pandemic restrictions. The conference served as an open forum for the sharing and spreading of the newest ideas and latest research findings among all those involved in any aspect of applied mathematics, modeling and computer sim...
Haematology Nursing
Haematology Nursing is a comprehensive handbook, with a nursing focus, on the care and management of patients with haematological disorders. Divided into four sections, the first provides an introduction to haematology, looking at haemopoiesis, immunology and genetics. Section Two covers non-malignant haematology, including anaemia, haemoglobinopathies and haemochromatosis. Section Three explores the pathophysiology, care and management of myeloproliferative and lymphoproliferative disorders, including leukaemia, myeloma, and lymphoma. The final section provides information on various nursing care interventions, including blood transfusion, venous access devices, and palliative care. Aimed principally at nurses working in a variety of settings including haematology/oncology wards, medical/haematology wards, specialist bone marrow transplant centres, and community settings, Haematology Nursing is an essential and much-needed reference guide.
UK Success Stories in Industrial Mathematics
This publication showcases the work of UK mathematicians and statisticians by describing industrial problems that have been successfully solved, together with a summary of the financial and/or societal impact that arose from the work. The articles are grouped by sector, and include contributions to climate modelling, engineering and health. The articles are based on Impact Case Studies that were submitted to the Research Excellence Framework (REF2014), a UK government sponsored exercise that assessed the research quality within UK universities. There are many publications in the realm of ‘popular mathematics’ as well as a vast research literature that underpins this. This work is aimed a...
Nonlinear Structural Dynamics and Damping
This book compiles recent research in the field of nonlinear dynamics, vibrations and damping applied to engineering structures. It addresses the modeling of nonlinear vibrations in beams, frames and complex mechanical systems, as well as the modeling of damping systems and viscoelastic materials applied to structural dynamics. The book includes several chapters related to solution techniques and signal analysis techniques. Last but not least, it deals with the identification of nonlinear responses applied to condition monitoring systems.
Reviews of Physiology, Biochemistry and Pharmacology 149
With contributions by numerous experts
Sporting Magazine
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