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MotorBoating
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Epigenetics and Chromatin
Epigenetics refers to heritable patterns of gene expression which do not depend on alterations of genomic DNA sequence. This book provides a state-of-the-art account of a few selected hot spots by scientists at the edge in this extremely active field. It puts special emphasis on two main streams of research. One is the role of post-translational modifications of proteins, mostly histones, on chromatin structure and accessibility. The other one deals with parental genomic imprinting, a process which allows to express a few selected genes from only one of the parental allele while extinguishing the other.
Gene Silencing
Gene silencing is a general term describing epigenetic processes of gene regulation. The term gene silencing is generally used to describe the 'switching off' of a gene by a mechanism other than genetic mutation. That is, a gene which would be expressed (turned on) under normal circumstances, is switched off by machinery in the cell. Genes are regulated at either the transcriptional or post-transcriptional level. Transcriptional gene silencing is the result of histone modifications, creating an environment of heterochromatin around a gene that makes it inaccessible to transcriptional machinery (RNA polymerase, transcription factors, etc.). Post-transcriptional gene silencing is the result of mRNA of a particular gene being destroyed. The destruction of the mRNA prevents translation to form an active gene product (in most cases, a protein). A common mechanism of post-transcriptional gene silencing is RNAi. Both transcriptional and post-transcriptional gene silencing are used to regulate endogenous genes. This book presents the latest research in this important field.
Specific Gene Expression and Epigenetics
This new volume on gene expression and epigenetics discusses environmental effects related to specific gene expression. The book also shows methods for bioinformatic analysis of the epigenome. The book is broken into two sections: the first looks at eukaryotic DNA methylation and the second addresses how to integrate genomic medicine into clinical practice. The book includes chapters on these topics: • Gene expression in colon cancer tissue • Epigenetics in human acute kidney injury • Embryologically relevant candidate genes in MRKH patients • DNA methylation in common skeletal disorders • Causal relationships in genomics • Predicting severe asthma exacerbations in children • Epigenetic understanding of gene-environment interactions in psychiatric disorders
The Boron Arsenides
Boron Arsenide offers very interesting electronic properties, as well as a high thermal conductivity; nearly 10 times higher than that of silicon. It has been hailed as ‘the best semiconductor material ever found’. The present book presents a detailed review of this material and its potential applications. The materials covered include Icosahedral Boron Arsenide, Hexagonal Boron Arsenide, Amorphous Boron Arsenide and Cubic Boron Arsenide. The book references 166 original resources with their direct web links for in-depth reading. Keywords: Boron Arsenides, Electron Mobility, Hole Mobility, Band-gap, Monolayers, Defects, Mechanical Properties, Photo-electrodes, Thermal Conductivity, Heat-spreading.
AIDS Bibliography
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Official Register
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Circulating Tumor Cells
Introduces the reader to Circulating Tumor Cells (CTCs), their isolation method and analysis, and commercially available platforms Presents the historical perspective and the overview of the field of circulating tumor cells (CTCs) Discusses the state-of-art methods for CTC isolation, ranging from the macro- to micro-scale, from positive concentration to negative depletion, and from biological-property-enabled to physical-property-based approaches Details commercially available CTC platforms Describes post-isolation analysis and clinical translation Provides a glossary of scientific terms related to CTCs
Optoelectronic Devices
Tremendous progress has been made in the last few years in the growth, doping and processing technologies of the wide bandgap semiconductors. As a result, this class of materials now holds significant promis for semiconductor electronics in a broad range of applications. The principal driver for the current revival of interest in III-V Nitrides is their potential use in high power, high temperature, high frequency and optical devices resistant to radiation damage. This book provides a wide number of optoelectronic applications of III-V nitrides and covers the entire process from growth to devices and applications making it essential reading for those working in the semiconductors or microelectronics. Broad review of optoelectronic applications of III-V nitrides
